Dynamic Metabolic Changes during the First 3 Months after 90Y-Ibritumomab Tiuxetan Radioimmunotherapy
| Title: | Dynamic Metabolic Changes during the First 3 Months after 90Y-Ibritumomab Tiuxetan Radioimmunotherapy |
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| Authors: | Miwako Takahashi, Toshimitsu Momose, Keitaro Koyama, Motoshi Ichikawa, Mineo Kurokawa, Kuni Ohtomo |
| Source: | The Scientific World Journal, Vol 2014 (2014) |
| Publisher Information: | Wiley, 2014. |
| Publication Year: | 2014 |
| Collection: | LCC:Technology LCC:Medicine LCC:Science |
| Subject Terms: | Technology, Medicine, Science |
| More Details: | Objective. To elucidate the time course of tumor metabolism during the first 3 months after 90Y-ibritumomab tiuxetan radioimmunotherapy (RIT) in patients with refractory malignant lymphoma. Materials and Methods. Seven patients with recurrent follicular lymphoma underwent FDG-PET imaging before and after 1-, 4-, and 12-week RIT with 90Y-ibritumomab tiuxetan. Tumor metabolic activity on FDG-PET scans was assessed as the maximum standard uptake value (SUVmax). Results. Decrease in metabolism was detected 1 week after RIT. In the most decreased lesion, SUVmax decreased to 20% of the baseline value during the first week. Most lesions continued to decrease for up to 4 weeks. Some lesions showed increased metabolism from 4 to 12 weeks, while the level of FDG accumulations at 12 weeks was still lower than the baseline. Conclusions. Tumor response to RIT could be observed as early as 1 week after the administration of RIT. After tumor activity decreases, the metabolism may increase at least between 4 and 12 weeks. It suggests that the metabolic changes should be carefully evaluated during this period. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2356-6140 1537-744X |
| Relation: | https://doaj.org/toc/2356-6140; https://doaj.org/toc/1537-744X |
| DOI: | 10.1155/2014/368947 |
| Access URL: | https://doaj.org/article/e4d1d6b5d8144424bc74527fa28c593b |
| Accession Number: | edsdoj.4d1d6b5d8144424bc74527fa28c593b |
| Database: | Directory of Open Access Journals |
| ISSN: | 23566140 1537744X |
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| DOI: | 10.1155/2014/368947 |
| Published in: | The Scientific World Journal |
| Language: | English |