Academic Journal
Ketogenic Diet Improves Sleep Quality and Daytime Sleepiness in Chronic Migraine: A Pilot Study
| Title: | Ketogenic Diet Improves Sleep Quality and Daytime Sleepiness in Chronic Migraine: A Pilot Study |
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| Authors: | Yan Tereshko, Simone Dal Bello, Enrico Belgrado, Cherubino Di Lorenzo, Alice Pittino, Francesca Filippi, Francesca Valdemarin, Christian Lettieri, Gian Luigi Gigli, Annacarmen Nilo, Gaia Pellitteri, Giovanni Merlino, Mariarosaria Valente |
| Source: | Neurology International, Vol 16, Iss 6, Pp 1203-1213 (2024) |
| Publisher Information: | MDPI AG, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Medicine LCC:Internal medicine LCC:Neurosciences. Biological psychiatry. Neuropsychiatry |
| Subject Terms: | ketogenic diet, migraine, headache, migraine prevention, low-glycemic index diet, 2:1 ketogenic diet, Medicine, Internal medicine, RC31-1245, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571 |
| More Details: | Aims: The aim of this study is to assess the sleep quality and daytime sleepiness improvement in chronic migraineurs after 6 months of a 2:1 KD (ketogenic diet) and LGID (low-glycemic-index diet). Methods: Twenty-six patients underwent 2:1 KD (11 patients) and LGID (15 patients). PSQI (Pittsburgh sleep quality index) and ESS (Epworth sleepiness scale) were administered at the baseline and the 3-month and 6-month follow-up. MIDAS (Migraine Disability Assessment), HIT-6 (Headache Impact Test 6), migraine frequency (migraine days per month), migraine intensity, BMI (Body Mass Index), FM (Fat Mass), and FFM (Fat-Free Mass) were also assessed. Results: PSQI (F1.544, 38.606 = 7.250; p = 0.004), ESS (F1.988, 49.708 = 9.938; p < 0.001), HIT-6 (F1.432, 35.805 = 12.693; p < 0.001), migraine frequency (F1.522, 38.041 = 23.070; p < 0.001), migraine intensity (F1.949, 48.721 = 18.798; p < 0.001), BMI (F1.274, 31.857 = 38.191; p < 0.001), and FM (F1.245, 31.134 = 45.487; p < 0.001) improved significantly. The MIDAS (F1.005, 25.121 = 3.037; p = 0.093) and the FMM (F1.311, 32.784 = 1.741; p = 0.197) did not improve significantly. The ESS (p = 0.712) and PSQI (p = 0.776) data at 3-month and 6-month follow-ups did not differ significantly, as well as for migraine frequency, migraine intensity, BMI, FM, and HIT-6. A mild correlation emerged between the mean FM and mean ESS reduction during the 6 months (r = 0.497, p = 0.010). Conclusions: Six months of LGID and 2:1 KD can improve sleep quality and daytime sleepiness in patients with chronic migraine. The effectiveness on migraine, sleep quality, and daytime sleepiness does not differ significantly between the 3-month and 6-month follow-up periods. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 16060091 2035-8377 |
| Relation: | https://www.mdpi.com/2035-8377/16/6/91; https://doaj.org/toc/2035-8377 |
| DOI: | 10.3390/neurolint16060091 |
| Access URL: | https://doaj.org/article/4d070c8d1f80437dbf52e92be0791dae |
| Accession Number: | edsdoj.4d070c8d1f80437dbf52e92be0791dae |
| Database: | Directory of Open Access Journals |
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| ISSN: | 16060091 20358377 |
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| DOI: | 10.3390/neurolint16060091 |
| Published in: | Neurology International |
| Language: | English |