GSTM1-null and GSTT1-active genotypes as risk determinants of primary open angle glaucoma among smokers
| Title: | GSTM1-null and GSTT1-active genotypes as risk determinants of primary open angle glaucoma among smokers |
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| Authors: | Miroslav Stamenkovic, Vesna Lukic, Sonja Suvakov, Tatjana Simic, Ivan Sencanic, Marija Pljesa-Ercegovac, Vesna Jaksic, Sinisa Babovic, Marija Matic, Aleksandra Radosavljevic, Ana Savic-Radojevic, Tatjana Djukic |
| Source: | International Journal of Ophthalmology, Vol 11, Iss 9, Pp 1514-1520 (2018) |
| Publisher Information: | Press of International Journal of Ophthalmology (IJO PRESS), 2018. |
| Publication Year: | 2018 |
| Collection: | LCC:Ophthalmology |
| Subject Terms: | 1520, GSTM1, GSTT1, primary open angle glaucoma risk, smoking, hypertension, diabetes mellitus, Ophthalmology, RE1-994 |
| More Details: | AIM: To evaluate glutathione transferase theta 1 and mu 1 (GSTT1 and GSTM1) polymorphisms as determinants of primary open angle glaucoma (POAG) risk, independently or in combination with cigarette smoking, hypertension and diabetes mellitus. METHODS: A case-control study with 102 POAG patients and 202 age and gender-matched controls was carried out. Multiplex-polymerase chain reaction method was used for the analysis of GSTM1 and GSTT1 polymorphisms. The differences between two groups were tested by the t-test or χ2 test. Logistic regression analysis was used for assessing the risk for disease development. RESULTS: The presence of GSTM1-null genotype did not contribute independently towards the risk of POAG. However, individuals with GSTT1-active genotype were at almost two-fold increased risk to develop glaucoma (P=0.044) which increased up to 4.36 when combined with GSTM1-null carriers (P=0.024). When glutathione transferase (GST) genotypes were analyzed in association with cigarette smoking, hypertension and diabetes, only carriers of GSTT1-active genotype had significantly increased risk of POAG development in comparison with GSTT1-null genotype individuals with no history of smoking, hypertension and diabetes, respectively (OR=3.52, P=0.003; OR=10.02, P |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2222-3959 2227-4898 |
| Relation: | http://www.ijo.cn/en_publish/2018/9/20180914.pdf; https://doaj.org/toc/2222-3959; https://doaj.org/toc/2227-4898 |
| DOI: | 10.18240/ijo.2018.09.14 |
| Access URL: | https://doaj.org/article/4ce69f1be9354bd3b749d392b36ccb2c |
| Accession Number: | edsdoj.4ce69f1be9354bd3b749d392b36ccb2c |
| Database: | Directory of Open Access Journals |
| ISSN: | 22223959 22274898 |
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| DOI: | 10.18240/ijo.2018.09.14 |
| Published in: | International Journal of Ophthalmology |
| Language: | English |