Bibliographic Details
| Title: |
Disease activity trajectories from childhood to adulthood in the population-based Nordic juvenile idiopathic arthritis cohort |
| Authors: |
Kristiina Aalto, Anders Fasth, Troels Herlin, Marite Rygg, Ellen Berit Nordal, LILLEMOR BERNTSON, Mia Glerup, Veronika Rypdal, Martin Rypdal, Ellen Arnstad, Charlotte Myrup, Suvi Peltoniemi |
| Source: |
RMD Open, Vol 10, Iss 1 (2024) |
| Publisher Information: |
BMJ Publishing Group, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Medicine |
| Subject Terms: |
Medicine |
| More Details: |
Objectives To identify long-term disease activity trajectories from childhood to adulthood by using the clinical Juvenile Arthritis Disease Activity Score (cJADAS10) in juvenile idiopathic arthritis (JIA). Second, to evaluate the contribution of the cJADAS10 components and explore characteristics associated with active disease at the 18-year follow-up.Methods Patients with onset of JIA in 1997–2000 were followed for 18 years in the population-based Nordic JIA cohort. We used a discrete mixture model for longitudinal clustering of the cJADAS10 and its components. We assessed factors potentially associated with higher scores on the patient’s global assessment of well-being (PaGA) by hierarchical clustering and correlation analysis.Results Four disease activity trajectories were identified based on the cJADAS10 components among 427 patients. In trajectory-group 2, the PaGA and the physician’s global assessment of disease activity (PhGA) increased significantly during the course, but not the active joint count. The increase in the PaGA was significantly higher than the increases in the PhGA and the active joint count (p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2056-5933 |
| Relation: |
https://rmdopen.bmj.com/content/10/1/e003759.full; https://doaj.org/toc/2056-5933 |
| DOI: |
10.1136/rmdopen-2023-003759 |
| Access URL: |
https://doaj.org/article/4cd2d8c44af1418fa04862043bcbc03a |
| Accession Number: |
edsdoj.4cd2d8c44af1418fa04862043bcbc03a |
| Database: |
Directory of Open Access Journals |
