Bibliographic Details
| Title: |
Antitumor effects of fecal microbiota transplantation: Implications for microbiome modulation in cancer treatment |
| Authors: |
Hui Xu, Chenxi Cao, Yuqing Ren, Siyuan Weng, Long Liu, Chunguang Guo, Libo Wang, Xinwei Han, Jianzhuang Ren, Zaoqu Liu |
| Source: |
Frontiers in Immunology, Vol 13 (2022) |
| Publisher Information: |
Frontiers Media S.A., 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Immunologic diseases. Allergy |
| Subject Terms: |
cancer, fecal microbiota transplantation, FMT, gut microbiota, immunotherapy, Immunologic diseases. Allergy, RC581-607 |
| More Details: |
Fecal microbiome transplantation (FMT) from healthy donors is one of the techniques for restoration of the dysbiotic gut, which is increasingly being used to treat various diseases. Notably, mounting evidence in recent years revealed that FMT has made a breakthrough in the oncology treatment area, especially by improving immunotherapy efficacy to achieve antitumor effects. However, the mechanism of FMT in enhancing antitumor effects of immune checkpoint blockers (ICBs) has not yet been fully elucidated. This review systematically summarizes the role of microbes and their metabolites in the regulation of tumor immunity. We highlight the mechanism of action of FMT in the treatment of refractory tumors as well as in improving the efficacy of immunotherapy. Furthermore, we summarize ongoing clinical trials combining FMT with immunotherapy and further focus on refined protocols for the practice of FMT in cancer treatment, which could guide future directions and priorities of FMT scientific development. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1664-3224 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fimmu.2022.949490/full; https://doaj.org/toc/1664-3224 |
| DOI: |
10.3389/fimmu.2022.949490 |
| Access URL: |
https://doaj.org/article/4c4c70d84303458686ac878391c1a045 |
| Accession Number: |
edsdoj.4c4c70d84303458686ac878391c1a045 |
| Database: |
Directory of Open Access Journals |
