Bibliographic Details
| Title: |
Serum vascular endothelial growth factor associated with the progression of granulosa cell tumor: a report of two cases |
| Authors: |
Kazuki Takasaki, Takayuki Ichinose, Yuko Miyagawa, Shiho Fukui, Kei Hashimoto, Haruka Nishida, Yuko Takahashi, Haruko Hiraike, Koji Saito, Yuko Sasajima, Kazunori Nagasaka |
| Source: |
Journal of Ovarian Research, Vol 16, Iss 1, Pp 1-5 (2023) |
| Publisher Information: |
BMC, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Gynecology and obstetrics |
| Subject Terms: |
Granulosa cell tumor, Vascular endothelial growth factor, Chemotherapy, Gynecology and obstetrics, RG1-991 |
| More Details: |
Abstract Background Granulosa cell tumors (GCTs) account for approximately 2% of ovarian malignancies and are considered a rare type of ovarian cancer. GCTs are characterized by irregular genital bleeding after menopause due to female hormone production as well as late recurrence around 5–10 years after initial treatment. In this study, we investigated two cases of GCTs to find a biomarker that can be used to evaluate the treatment and predict recurrence. Case presentation Case 1 was a 56-year-old woman who presented to our hospital with abdominal pain and distention. An abdominal tumor was found, and GCTs were diagnosed. Serum vascular endothelial growth factor (VEGF) levels decreased after surgery. Case 2 involved a 51-year-old woman with refractory GCTs. Carboplatin–paclitaxel combination therapy and bevacizumab were administered after the tumor resection. After chemotherapy, a decline in VEGF levels was observed, but serum VEGF levels increased again with disease progression. Conclusions VEGF expression may be of clinical importance in GCTs as a clinical biomarker for disease progression, which may be used to determine the efficacy of bevacizumab against GCTs. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1757-2215 |
| Relation: |
https://doaj.org/toc/1757-2215 |
| DOI: |
10.1186/s13048-023-01197-z |
| Access URL: |
https://doaj.org/article/4c04097d7f4a4180824bca4bb02b70d6 |
| Accession Number: |
edsdoj.4c04097d7f4a4180824bca4bb02b70d6 |
| Database: |
Directory of Open Access Journals |
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