Bibliographic Details
| Title: |
The Ig CAM CAR is Implicated in Cardiac Development and Modulates Electrical Conduction in the Mature Heart |
| Authors: |
Claudia Matthäus, Jadwiga Schreiber, René Jüttner, Fritz G. Rathjen |
| Source: |
Journal of Cardiovascular Development and Disease, Vol 1, Iss 1, Pp 111-120 (2014) |
| Publisher Information: |
MDPI AG, 2014. |
| Publication Year: |
2014 |
| Collection: |
LCC:Diseases of the circulatory (Cardiovascular) system |
| Subject Terms: |
CAR, cell adhesion, IgCAM, cardiac development, electrical conduction, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| More Details: |
The coxsackievirus and adenovirus receptor (CAR, CXADR) is a multi-functional cell adhesion molecule which forms with CLMP, BT-IgSF, ESAM and CTX a structural subgroup within the Ig superfamily. These proteins share an overall domain organization with two extracellular Ig domains, a transmembrane region and a cytoplasmic tail which includes a PDZ binding motif. CAR is strongly expressed in brain and heart during embryonic development and becomes down-regulated in early postnatal stages. Cell adhesion experiments, binding studies and as well as crystallographic investigations on the extracellular domain reveal a flexible ectodomain for CAR that mediates homophilic and heterophilic binding. Several animal models showed an essential role for CAR during embryonic heart development and for electrical conduction between neighboring cardiomyocytes at mature stages. CAR gets re-expressed in diseased or damaged cardiac tissue, probably to induce regeneration and remodeling of the cardiac muscle. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2308-3425 |
| Relation: |
http://www.mdpi.com/2308-3425/1/1/111; https://doaj.org/toc/2308-3425 |
| DOI: |
10.3390/jcdd1010111 |
| Access URL: |
https://doaj.org/article/e4b664da172a4e9fbdcb20186ea6d589 |
| Accession Number: |
edsdoj.4b664da172a4e9fbdcb20186ea6d589 |
| Database: |
Directory of Open Access Journals |
