CD73, a significant protein in liver diseases
| Title: | CD73, a significant protein in liver diseases |
|---|---|
| Authors: | Huilian Shi, Heng Dai, Qianqian Sun, Siliang Wang, Yuanyuan Chen |
| Source: | Frontiers in Medicine, Vol 10 (2023) |
| Publisher Information: | Frontiers Media S.A., 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Medicine (General) |
| Subject Terms: | CD73, adenosine pathway, liver diseases, HBV, HCV, Medicine (General), R5-920 |
| More Details: | Purine adenosine pathway exists widely in the body metabolism, and is involved in regulating various physiological processes. It is one of the important pathways of environmental regulation in human body. CD73 is essentially a protease that catalyzes further dephosphorylation of extracellular adenine nucleotides, hydrolyzing extracellular AMP to adenosine and phosphate. CD73 is an important part of the adenosine signaling pathway. Studies have shown that CD73-mediated adenosine pathway can convert the inflammatory ATP into the immunosuppressant adenosine. This paper aims to summarize the relevant effects of CD73 in the occurrence, development and prognosis of liver diseases such as viral hepatitis, highlight the important role of CD73 in liver diseases, especially in viral hepatitis such as HBV and HCV, and explore new clinical ideas for future treatment targets of liver diseases. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2296-858X 55292194 |
| Relation: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1147782/full; https://doaj.org/toc/2296-858X |
| DOI: | 10.3389/fmed.2023.1147782 |
| Access URL: | https://doaj.org/article/4b55292194da40bf9ba23898b233ebd9 |
| Accession Number: | edsdoj.4b55292194da40bf9ba23898b233ebd9 |
| Database: | Directory of Open Access Journals |
| ISSN: | 2296858X 55292194 |
|---|---|
| DOI: | 10.3389/fmed.2023.1147782 |
| Published in: | Frontiers in Medicine |
| Language: | English |