Bibliographic Details
| Title: |
Propensity-score-matched comparison of safety, efficacy, and outcome of intravascular lithotripsy versus high-pressure PTCA in coronary calcified lesions |
| Authors: |
Adem Aksoy, Vedat Tiyerili, Nora Jansen, Muntadher Al Zaidi, Maximillian Thiessen, Alexander Sedaghat, Marc Ulrich Becher, Felix Jansen, Georg Nickenig, Sebastian Zimmer |
| Source: |
International Journal of Cardiology: Heart & Vasculature, Vol 37, Iss , Pp 100900- (2021) |
| Publisher Information: |
Elsevier, 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Diseases of the circulatory (Cardiovascular) system |
| Subject Terms: |
Calcification, High-pressure PTCA, Lithotripsy, Shockwave, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| More Details: |
Background: Data regarding safety, efficacy, and outcome of intravascular lithotripsy (IVL) in comparison to standard techniques are lacking. This study sought to compare IVL with non-compliant high-pressure balloon percutaneous coronary angioplasty (PTCA). Methods and results: We performed a retrospective propensity-score-matched study to compare procedural success in 57 consecutive patients who received IVL-guided PCI in calcified coronary lesions with 171 matched patients who were treated with high-pressure PTCA with a non-compliant (NC)-balloon. The mean minimal lumen diameter (MLD) for the IVL group was 1.08 ± 0.51 mm, and the median percent diameter stenosis on quantitative angiography was 70.2% (interquartile range, 60.2–78.6%). MLD in the high-pressure dilatation group was 0.97 ± 0.43 mm, and the median percent diameter stenosis was 71.5% (interquartile range, 58.5–77.0%). IVL-guided PCI reduced median stenosis to 17.5% (interquartile range, 9.3–19.8%) with an acute gain of 0.93 ± 0.7 mm. High-pressure dilatation resulted in a final median stenosis of 19.3% (interquartile range, 13.33–28.5%). Procedural success was significantly higher (82.5% vs. 61.4%; p: 0.0035) in the IVL group. MACE through 12 months occurred in 10.5% of cases in the IVL group and in 11.1% of the high-pressure group (p = 0.22). Angiographic complications (coronary dissection, slow or no reflow, new coronary thrombus formation, abrupt vessel closure) were very low (0.2% vs. 0.12%). Conclusion: IVL resulted in a significantly higher rate of procedural success compared to high- pressure NC-balloon dilatation in patients with calcified coronary lesions. The rate of MACE through 12 months was similar to the standard therapy. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2352-9067 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2352906721001883; https://doaj.org/toc/2352-9067 |
| DOI: |
10.1016/j.ijcha.2021.100900 |
| Access URL: |
https://doaj.org/article/4b1450cb8577427ba4d2cf17dc207631 |
| Accession Number: |
edsdoj.4b1450cb8577427ba4d2cf17dc207631 |
| Database: |
Directory of Open Access Journals |
