Bibliographic Details
| Title: |
Antioxidant Activity of Planar Catechin Conjugated with Trolox |
| Authors: |
Wakana Shimizu, Yoshimi Shoji, Kei Ohkubo, Hiromu Ito, Ikuo Nakanishi, Kiyoshi Fukuhara |
| Source: |
Antioxidants, Vol 13, Iss 10, p 1165 (2024) |
| Publisher Information: |
MDPI AG, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Therapeutics. Pharmacology |
| Subject Terms: |
catechin, trolox, tocopherol, antioxidant activity, Therapeutics. Pharmacology, RM1-950 |
| More Details: |
Planar catechin (PCat), a natural antioxidant with a fixed 3D catechin structure on a plane, exhibits radical-scavenging activity approximately five times stronger than the conventional catechin. We synthesized a compound, PCat-TrOH, by binding Trolox (TrOH), an α-tocopherol analog, to PCat to enhance its antioxidant effect against oxidative stress, such as lipid peroxidation. TrOH shows radical-scavenging activity about 6.5 times greater than PCat, and PCat-TrOH exhibited a similar level of radical-scavenging activity to TrOH. Additionally, PCat-TrOH demonstrated twice the radical-scavenging activity against reactive oxygen species compared to PCat or TrOH. This compound is also expected to exhibit an excellent antioxidant effect against lipid peroxidation caused by radical chain reactions, through interactions with vitamin C, similar to that in the case of α-tocopherol. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2076-3921 |
| Relation: |
https://www.mdpi.com/2076-3921/13/10/1165; https://doaj.org/toc/2076-3921 |
| DOI: |
10.3390/antiox13101165 |
| Access URL: |
https://doaj.org/article/a4acb9e80e524b6483f72df6bd3ea9f2 |
| Accession Number: |
edsdoj.4acb9e80e524b6483f72df6bd3ea9f2 |
| Database: |
Directory of Open Access Journals |
