Bibliographic Details
| Title: |
DOT1L inhibition reveals a distinct subset of enhancers dependent on H3K79 methylation |
| Authors: |
Laura Godfrey, Nicholas T. Crump, Ross Thorne, I-Jun Lau, Emmanouela Repapi, Dimitra Dimou, Alastair L. Smith, Joe R. Harman, Jelena M. Telenius, A. Marieke Oudelaar, Damien J. Downes, Paresh Vyas, Jim R. Hughes, Thomas A. Milne |
| Source: |
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019) |
| Publisher Information: |
Nature Portfolio, 2019. |
| Publication Year: |
2019 |
| Collection: |
LCC:Science |
| Subject Terms: |
Science |
| More Details: |
Histone 3 lysine 79 is mono (me1), di (me2), or tri (me3) methylated by the methyltransferase DOT1L. Here the authors reveal a group of enhancers defined by H3K79me2/3 which regulates enhancer-promoter interactions and other key enhancer features in MLL-AF4 leukemia cells. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2041-1723 |
| Relation: |
https://doaj.org/toc/2041-1723 |
| DOI: |
10.1038/s41467-019-10844-3 |
| Access URL: |
https://doaj.org/article/e4a9cce559524c16a138443251705752 |
| Accession Number: |
edsdoj.4a9cce559524c16a138443251705752 |
| Database: |
Directory of Open Access Journals |
