Effects of melatonin supplementation on oxidative stress, and inflammatory biomarkers in diabetic patients with chronic kidney disease: a double-blind, randomized controlled trial
| Title: | Effects of melatonin supplementation on oxidative stress, and inflammatory biomarkers in diabetic patients with chronic kidney disease: a double-blind, randomized controlled trial |
|---|---|
| Authors: | Sara Sadeghi, Amirahmad Nassiri, Monir Sadat Hakemi, Fatemeh Hosseini, Fatemeh Pourrezagholie, Fatemeh Naeini, Aylar Nadiri Niri, Hossein Imani, Hamed Mohammadi |
| Source: | BMC Nutrition, Vol 11, Iss 1, Pp 1-10 (2025) |
| Publisher Information: | BMC, 2025. |
| Publication Year: | 2025 |
| Collection: | LCC:Nutrition. Foods and food supply LCC:Food processing and manufacture LCC:Medicine (General) |
| Subject Terms: | Chronic kidney disease, Melatonin, Oxidative stress, Inflammation, Nutrition. Foods and food supply, TX341-641, Food processing and manufacture, TP368-456, Medicine (General), R5-920 |
| More Details: | Abstract Background and objectives Chronic kidney disease (CKD) is a progressive illness linked to higher rates of morbidity and death. One of the main causes of CKD is diabetes mellitus (DM), and oxidative stress is essential to the disease's development. It has been demonstrated that the natural antioxidant melatonin reduces inflammation and oxidative damage in renal tissues. Given the lack of robust evidence, this double-blind clinical trial sought to investigate the effects of melatonin supplementation on oxidative stress and inflammatory markers in diabetic CKD patients. Materials and methods This trial included 41 diabetic patients with CKD (stages 3–4) from Shariati Hospital, Tehran, Iran. For ten weeks, participants were randomized to receive either a placebo or 5 mg of melatonin twice a day. Baseline characteristics, dietary intake, physical activity, and anthropometric measurements were recorded. Oxidative stress (TAC, TOS, MDA) and inflammatory markers (IL-6, hs-CRP) were measured before and after the intervention. Statistical analysis was performed using SPSS, with significance set at p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2055-0928 |
| Relation: | https://doaj.org/toc/2055-0928 |
| DOI: | 10.1186/s40795-025-01026-0 |
| Access URL: | https://doaj.org/article/4a956891b3cc413fa8283ea8097a88ec |
| Accession Number: | edsdoj.4a956891b3cc413fa8283ea8097a88ec |
| Database: | Directory of Open Access Journals |
| ISSN: | 20550928 |
|---|---|
| DOI: | 10.1186/s40795-025-01026-0 |
| Published in: | BMC Nutrition |
| Language: | English |