Academic Journal
The association between acetylsalicylic acid and subarachnoid haemorrhage: the Framingham Heart Study
| Title: | The association between acetylsalicylic acid and subarachnoid haemorrhage: the Framingham Heart Study |
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| Authors: | Frederick Ewbank, Jacqueline Birks, Diederik Bulters |
| Source: | Scientific Reports, Vol 13, Iss 1, Pp 1-7 (2023) |
| Publisher Information: | Nature Portfolio, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Medicine LCC:Science |
| Subject Terms: | Medicine, Science |
| More Details: | Abstract Studies investigating the association between acetylsalicylic acid (ASA) use and spontaneous subarachnoid haemorrhage (SAH) in the general population have produced conflicting results. The aim of this study is to clarify the relationship between SAH and ASA. We included all participants who reported on ASA use during interim examinations of the Framingham Heart Study Cohorts. Using Cox proportional-hazards regression modelling, we estimated the hazard ratio (HR) associated with ASA use. 7692 participants were included in this study. There were 30 cases of SAH during follow up, with an estimated incidence of 10.0 per 100,000 person- years (CI 6.90–14.15). Univariate analysis showed no association between regular ASA use and SAH (HR, 0.33 [0.08–1.41]; p = 0.14). This was similar when accounting for smoking (HR, 0.35 [0.08–1.51]; p = 0.16). Using a large longitudinal dataset from the Framingham Heart Study, we observed some evidence suggesting fewer SAH in those participants taking regular ASA. However, multivariate statistical analysis showed no significant association between ASA use and SAH. Due to the low incidence of SAH in the general population, the absolute number of SAH events was low and it remains uncertain if a significant effect would become apparent with more follow up. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2045-2322 |
| Relation: | https://doaj.org/toc/2045-2322 |
| DOI: | 10.1038/s41598-023-33570-9 |
| Access URL: | https://doaj.org/article/4a59b838739e48efb8ea0e43d8dfd605 |
| Accession Number: | edsdoj.4a59b838739e48efb8ea0e43d8dfd605 |
| Database: | Directory of Open Access Journals |
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| ISSN: | 20452322 |
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| DOI: | 10.1038/s41598-023-33570-9 |
| Published in: | Scientific Reports |
| Language: | English |