Bibliographic Details
| Title: |
L-Theanine Prolongs the Lifespan by Activating Multiple Molecular Pathways in Ultraviolet C-Exposed Caenorhabditis elegans |
| Authors: |
Liangwen Chen, Guijie Chen, Tingting Gai, Xiuhong Zhou, Jinchi Zhu, Ruiyi Wang, Xuemei Wang, Yujie Guo, Yun Wang, Zhongwen Xie |
| Source: |
Molecules, Vol 29, Iss 11, p 2691 (2024) |
| Publisher Information: |
MDPI AG, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Organic chemistry |
| Subject Terms: |
L-theanine, UVC, mitochondrial DNA damage, C. elegans, lifespan, Organic chemistry, QD241-441 |
| More Details: |
L-theanine, a unique non-protein amino acid, is an important bioactive component of green tea. Previous studies have shown that L-theanine has many potent health benefits, such as anti-anxiety effects, regulation of the immune response, relaxing neural tension, and reducing oxidative damage. However, little is known concerning whether L-theanine can improve the clearance of mitochondrial DNA (mtDNA) damage in organisms. Here, we reported that L-theanine treatment increased ATP production and improved mitochondrial morphology to extend the lifespan of UVC-exposed nematodes. Mechanistic investigations showed that L-theanine treatment enhanced the removal of mtDNA damage and extended lifespan by activating autophagy, mitophagy, mitochondrial dynamics, and mitochondrial unfolded protein response (UPRmt) in UVC-exposed nematodes. In addition, L-theanine treatment also upregulated the expression of genes related to mitochondrial energy metabolism in UVC-exposed nematodes. Our study provides a theoretical basis for the possibility that tea drinking may prevent mitochondrial-related diseases. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1420-3049 |
| Relation: |
https://www.mdpi.com/1420-3049/29/11/2691; https://doaj.org/toc/1420-3049 |
| DOI: |
10.3390/molecules29112691 |
| Access URL: |
https://doaj.org/article/4a3b04c10dad49c5b78b7ef2ade6c46e |
| Accession Number: |
edsdoj.4a3b04c10dad49c5b78b7ef2ade6c46e |
| Database: |
Directory of Open Access Journals |
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