Evolution and diversification of the nuclear envelope
| Title: | Evolution and diversification of the nuclear envelope |
|---|---|
| Authors: | Norma E. Padilla-Mejia, Alexandr A. Makarov, Lael D. Barlow, Erin R. Butterfield, Mark C. Field |
| Source: | Nucleus, Vol 12, Iss 1, Pp 21-41 (2021) |
| Publisher Information: | Taylor & Francis Group, 2021. |
| Publication Year: | 2021 |
| Collection: | LCC:Genetics LCC:Cytology |
| Subject Terms: | nuclear envelope, heterochromatin, lamina, proteome, evolution, eukaryogenesis, Genetics, QH426-470, Cytology, QH573-671 |
| More Details: | Eukaryotic cells arose ~1.5 billion years ago, with the endomembrane system a central feature, facilitating evolution of intracellular compartments. Endomembranes include the nuclear envelope (NE) dividing the cytoplasm and nucleoplasm. The NE possesses universal features: a double lipid bilayer membrane, nuclear pore complexes (NPCs), and continuity with the endoplasmic reticulum, indicating common evolutionary origin. However, levels of specialization between lineages remains unclear, despite distinct mechanisms underpinning various nuclear activities. Several distinct modes of molecular evolution facilitate organellar diversification and to understand which apply to the NE, we exploited proteomic datasets of purified nuclear envelopes from model systems for comparative analysis. We find enrichment of core nuclear functions amongst the widely conserved proteins to be less numerous than lineage-specific cohorts, but enriched in core nuclear functions. This, together with consideration of additional evidence, suggests that, despite a common origin, the NE has evolved as a highly diverse organelle with significant lineage-specific functionality. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 1949-1034 1949-1042 19491034 |
| Relation: | https://doaj.org/toc/1949-1034; https://doaj.org/toc/1949-1042 |
| DOI: | 10.1080/19491034.2021.1874135 |
| Access URL: | https://doaj.org/article/4a3870a6bf0c424cabaa72ea0254c73a |
| Accession Number: | edsdoj.4a3870a6bf0c424cabaa72ea0254c73a |
| Database: | Directory of Open Access Journals |
| ISSN: | 19491034 19491042 |
|---|---|
| DOI: | 10.1080/19491034.2021.1874135 |
| Published in: | Nucleus |
| Language: | English |