Academic Journal
Multi-institutional Evaluation of Curative Intent Chemoradiotherapy for Patients With Clinical T1N0 Esophageal Adenocarcinoma
| Title: | Multi-institutional Evaluation of Curative Intent Chemoradiotherapy for Patients With Clinical T1N0 Esophageal Adenocarcinoma |
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| Authors: | Wei Deng, MD, Krishan R. Jethwa, MD, Karthik Gonuguntla, MD, Zhongxing Liao, MD, Harry H. Yoon, MD, Mariela Blum Murphy, MD, Michael G. Haddock, MD, Christopher L. Hallemeier, MD, Steven H. Lin, MD PhD |
| Source: | Advances in Radiation Oncology, Vol 5, Iss 5, Pp 951-958 (2020) |
| Publisher Information: | Elsevier, 2020. |
| Publication Year: | 2020 |
| Collection: | LCC:Medical physics. Medical radiology. Nuclear medicine LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: | Medical physics. Medical radiology. Nuclear medicine, R895-920, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: | Purpose: To evaluate the safety and efficacy of definitive chemoradiotherapy (CRT) for patients with clinical T1N0M0 esophageal adenocarcinoma. Methods and Materials: This was a retrospective study of patients with clinical T1N0 adenocarcinoma of the esophagus treated with curative-intent CRT between 2004 and 2017 at 2 tertiary care centers. Patients received CRT instead of esophagectomy owing to medical comorbidities or patient preference. Toxicities were evaluated according to Common Terminology Criteria for Adverse Events version 4.03. The Kaplan-Meier method was used to estimate overall, progression-free, and disease-specific survivals. Results: Twenty-eight patients were included for analysis. Median age was 76 years (range 55-90). The majority of patients were male (93%) and had a history of Barrett’s esophagus (71%). Tumor characteristics included distal esophagus location (93%), clinical stage T1b (86%), and median length of 2 cm (range, 1-9). Prior endoscopic resection was performed in 57%.The median follow-up was 44 months (range, 4-146). The acute grade 3 adverse events were observed in 7 patients (25%). One patient died of complications potentially related to chemoradiation. Eight patients (29%) had disease progression at a median of 7.6 months after CRT. First site of progression was local only (14%), local and regional (11%), or distant (4%). Salvage locally directed treatment was performed in 3 of 4 patients with local-only recurrence. The 3-year overall survival, progression-free, and disease-specific rates were 78%, 62%, and 81%, respectively. Conclusion: CRT is a safe and effective curative treatment strategy for select patients with clinical T1N0M0 esophageal adenocarcinoma. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2452-1094 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2452109420300786; https://doaj.org/toc/2452-1094 |
| DOI: | 10.1016/j.adro.2020.03.020 |
| Access URL: | https://doaj.org/article/c49f54d9fa6b428ab649943d058b8c26 |
| Accession Number: | edsdoj.49f54d9fa6b428ab649943d058b8c26 |
| Database: | Directory of Open Access Journals |
| ISSN: | 24521094 |
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| DOI: | 10.1016/j.adro.2020.03.020 |
| Published in: | Advances in Radiation Oncology |
| Language: | English |