Bibliographic Details
| Title: |
Tertiary lymphoid structures in gynecological cancers: prognostic role, methods for evaluating, antitumor immunity, and induction for therapy |
| Authors: |
Ke Zhang, Xiao Xie, Shuang-Lin Zheng, Yuan-Run Deng, Dan Liao, Hai-Chen Yan, Xi Kang, Hui-Ping Jiang, Sui-Qun Guo |
| Source: |
Frontiers in Oncology, Vol 13 (2023) |
| Publisher Information: |
Frontiers Media S.A., 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: |
tertiary lymphoid structures, gynecological cancers, favorable prognosis, antitumor immunity, therapeutic induction, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: |
Tertiary lymphoid structures (TLSs), referred to as tertiary lymphoid organs and lymphoid tissue neogenesis, are aggregates of immune cells that occur in nonlymphoid tissues. In recent years, it has been found that TLSs within the tumor microenvironment have been associated with local adaptive immune immunity against cancer and favorable prognosis in several human solid tumors, including gynecological cancers. The issue of the prognosis of gynecological cancers, including endometrial, cervical, and ovarian cancer, is an enormous challenge that many clinical doctors and researchers are now facing. Concerning the predictive prognostic role of TLSs, effective evaluation, and quantification of TLSs in human tissues may be used to assist gynecologists in assessing the clinical outcome of gynecological cancer patients. This review summarizes the current knowledge of TLSs in gynecological cancers, mainly focusing on the potential mechanism of TLS neogenesis, methods for evaluating TLSs, their prognostic value, and their role in antitumor immune immunity. This review also discusses the new therapeutic methods currently being explored in gynecological cancers to induce the formation of TLSs. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2234-943X |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fonc.2023.1276907/full; https://doaj.org/toc/2234-943X |
| DOI: |
10.3389/fonc.2023.1276907 |
| Access URL: |
https://doaj.org/article/49f1503b15aa4f7a882d3612b8ea97b3 |
| Accession Number: |
edsdoj.49f1503b15aa4f7a882d3612b8ea97b3 |
| Database: |
Directory of Open Access Journals |
