Bibliographic Details
| Title: |
Exploring the impact of glutathione S-transferase (GST)-based metabolic resistance to insecticide on vector competence of Anopheles funestus for Plasmodium falciparum [version 2; peer review: 2 approved] |
| Authors: |
Cyrille Ndo, Edmond Kopya, Helen Irving, Charles Wondji |
| Source: |
Wellcome Open Research, Vol 4 (2019) |
| Publisher Information: |
Wellcome, 2019. |
| Publication Year: |
2019 |
| Collection: |
LCC:Medicine
LCC:Science |
| Subject Terms: |
Medicine, Science |
| More Details: |
Background: Malaria control heavily relies on insecticide-based interventions against mosquito vectors. However, the increasing spread of insecticide resistance is a major threat. The extent to which such resistance, notably metabolic resistance, influences the development of the Plasmodium parasite and its impact on overall malaria transmission remains poorly characterized. Here, we investigated whether glutathione S-transferase-based resistance could influence Plasmodium falciparum development in Anopheles funestus. Methods: Anopheles funestus females were infected with P. falciparum gametocytes and midguts were dissected at day 7 post infection for detection/quantification of oocysts. Infection parameters were compared between individuals with different L119F-GSTe2 genotypes, and the polymorphism of the GSTe2 gene was analyzed in infected and uninfected mosquito groups. Results: Overall, 403 An. funestus mosquitoes were dissected and genotyped. The frequency of the L119F-GSTe2 resistance allele was significantly higher in non-infected (55.88%) compared to infected (40.99%) mosquitoes (Fisher's exact test, P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2398-502X |
| Relation: |
https://wellcomeopenresearch.org/articles/4-52/v2; https://doaj.org/toc/2398-502X |
| DOI: |
10.12688/wellcomeopenres.15061.2 |
| Access URL: |
https://doaj.org/article/c49e307981b441b090678eeceaf5c77c |
| Accession Number: |
edsdoj.49e307981b441b090678eeceaf5c77c |
| Database: |
Directory of Open Access Journals |
