Exploring the Epicarp Potential from Acrocomia aculeata Fruits: Chemical Analysis, Antioxidant and Antimicrobial Activities
| Title: | Exploring the Epicarp Potential from Acrocomia aculeata Fruits: Chemical Analysis, Antioxidant and Antimicrobial Activities |
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| Authors: | Fabiane da Conceição Vieira Santos, Gabriel Rocha Martins, Sandra Regina da Silva Luiz, Isadora de Araújo Oliveira, Leandro Pereira da Silva, Antonio Jorge Ribeiro da Silva, Marcos Dias Pereira, Rosana Conrado Lopes, Celuta Sales Alviano, Daniela Sales Alviano Moreno |
| Source: | Antioxidants, Vol 14, Iss 2, p 181 (2025) |
| Publisher Information: | MDPI AG, 2025. |
| Publication Year: | 2025 |
| Collection: | LCC:Therapeutics. Pharmacology |
| Subject Terms: | macaúba epicarp, agricultural by-products, stilbenes, antioxidant activity, antimicrobial activity, mass spectrometry imaging, Therapeutics. Pharmacology, RM1-950 |
| More Details: | The interest in new sources of bioactive compounds has been driven by the search for natural antioxidants capable of attenuating the toxicity of reactive oxygen species, as well as the emergence of pathogens resistant to antimicrobials. In this sense, we explored the potential of the macaúba epicarp. Compounds such as piceatannol, 3,4,5,3′,5′-penta-hydroxy-trans-stilbene (PHS), and in lower amounts, resveratrol were identified in extracts through techniques such as medium-pressure liquid chromatography, HPLC-MS, and imaging mass spectrometry (IMS), which confirmed the exclusive localization of PHS and piceatannol in the outer epicarp. Extraction with aqueous acetone (Me2CO:H2O) and its EtOAC fraction showed the highest yields of stilbenes and, moreover, it efficiently increased the tolerance of Saccharomyces cerevisiae to oxidative stress. Additionally, the Me2CO:H2O extract presented antibacterial and anti-cryptococcal activity, with piceatannol and resveratrol increasing survival rates of Galleria mellonella subjected to fungal infection. In silico ADMET (absorption, distribution, metabolism, excretion and toxicity) analysis indicates low toxicity for piceatannol, PHS, and resveratrol, in addition to pharmacokinetic parameters that allow their use. These findings indicate the use of macaúba epicarp as a source of bioactive compounds valuable for the food, cosmetic, and pharmaceutical industries. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 14020181 2076-3921 |
| Relation: | https://www.mdpi.com/2076-3921/14/2/181; https://doaj.org/toc/2076-3921 |
| DOI: | 10.3390/antiox14020181 |
| Access URL: | https://doaj.org/article/493b134b71a14bf88013eaeac48f6b58 |
| Accession Number: | edsdoj.493b134b71a14bf88013eaeac48f6b58 |
| Database: | Directory of Open Access Journals |
| ISSN: | 14020181 20763921 |
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| DOI: | 10.3390/antiox14020181 |
| Published in: | Antioxidants |
| Language: | English |