Bibliographic Details
| Title: |
Multifaceted oncostatin M: novel roles and therapeutic potential of the oncostatin M signaling in rheumatoid arthritis |
| Authors: |
Liang Han, Jiahui Yan, Tingting Li, Weiji Lin, Yao Huang, Pan Shen, Xin Ba, Ying Huang, Kai Qin, Yinhong Geng, Huanhuan Wang, Kaifeng Zheng, Yafei Liu, Yu Wang, Zhe Chen, Shenghao Tu |
| Source: |
Frontiers in Immunology, Vol 14 (2023) |
| Publisher Information: |
Frontiers Media S.A., 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Immunologic diseases. Allergy |
| Subject Terms: |
oncostatin M (OSM), rheumatoid arthritis (RA), fibroblast-like synoviocytes (FLS), cytokines, cartilage and bone destruction, CD4+ T cell, Immunologic diseases. Allergy, RC581-607 |
| More Details: |
Rheumatoid arthritis (RA) is a self-immune inflammatory disease characterized by joint damage. A series of cytokines are involved in the development of RA. Oncostatin M (OSM) is a pleiotropic cytokine that primarily activates the Janus kinase (JAK)/signal transducer and activator of transcription (STAT) signaling pathway, the mitogen-activated protein kinase (MAPK) signaling pathway, and other physiological processes such as cell proliferation, inflammatory response, immune response, and hematopoiesis through its receptor complex. In this review, we first describe the characteristics of OSM and its receptor, and the biological functions of OSM signaling. Subsequently, we discuss the possible roles of OSM in the development of RA from clinical and basic research perspectives. Finally, we summarize the progress of clinical studies targeting OSM for the treatment of RA. This review provides researchers with a systematic understanding of the role of OSM signaling in RA, which can guide the development of drugs targeting OSM for the treatment of RA. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1664-3224 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fimmu.2023.1258765/full; https://doaj.org/toc/1664-3224 |
| DOI: |
10.3389/fimmu.2023.1258765 |
| Access URL: |
https://doaj.org/article/48f27e106fe94467a8bfb7bdcca33135 |
| Accession Number: |
edsdoj.48f27e106fe94467a8bfb7bdcca33135 |
| Database: |
Directory of Open Access Journals |
