Antioxidant and anti–inflammatory effects of Helichrysum plicatum DC. subsp. plicatum extract in an experimental model of acute urolithiasis
| Title: | Antioxidant and anti–inflammatory effects of Helichrysum plicatum DC. subsp. plicatum extract in an experimental model of acute urolithiasis |
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| Authors: | Selvinaz Yakan, Kıvılcım Eren Erdoğan, Yusuf Kenan Dağlıoğlu, Tuba Aydın, Ahmet Çakır |
| Source: | Revista Científica, Vol 35, Iss 1 (2025) |
| Publisher Information: | Universidad del Zulia, 2025. |
| Publication Year: | 2025 |
| Collection: | LCC:Cattle LCC:Veterinary medicine |
| Subject Terms: | Calcium oxalate crystals, urolithiasis, rat, thiobarbituric acid reactive substance (TBARS), Helichrysum plicatum DC. subsp. plicatum, Cattle, SF191-275, Veterinary medicine, SF600-1100 |
| More Details: | This study aimed to view the antioxidant and anti–inflammatory properties of Helichrysum plicatum DC. subsp. plicatum (HP) methanol extract on the urinary tract using an experimentally induced urolithiasis (U) model. The study included four groups: Group 1 was given a standard diet, Group 2 was given a diet added with HP, Group 3 was given a standard diet with induced urolithiasis, and Group 4 received an HP–supplemented diet with induced urolithiasis. Rats in Groups 2 and 4 were administered 500 mg·kg-1·day-1 of HP via gavage feeding for 21 days. Urolithiasis was induced in Groups 3 and 4 by administering 1% ethylene glycol and 1% ammonium chloride in their swig water for 21 days to create a calcium oxalate (CaOx) urolithiasis model. The study analyzed plasma concentrations of thiobarbituric acid reactive substances (TBARS), an indicator of serum oxidative stress (OS), HP, and HP levels. Additionally, oxalate (Ox), urea, calcium, and creatinine clearance levels were measured in both blood and urine, and routine histological evaluations were conducted. The results indicated important higher concentrations of HP in the groups given HP (P |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English Spanish; Castilian |
| ISSN: | 0798-2259 2521-9715 |
| Relation: | https://www.produccioncientificaluz.org/index.php/cientifica/article/view/43314; https://doaj.org/toc/0798-2259; https://doaj.org/toc/2521-9715 |
| DOI: | 10.52973/rcfcv-e35502 |
| Access URL: | https://doaj.org/article/48d0242e99d84270a79815edb89a3b04 |
| Accession Number: | edsdoj.48d0242e99d84270a79815edb89a3b04 |
| Database: | Directory of Open Access Journals |
| ISSN: | 07982259 25219715 |
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| DOI: | 10.52973/rcfcv-e35502 |
| Published in: | Revista Científica |
| Language: | English Spanish; Castilian |