Bibliographic Details
| Title: |
Fractional Skin Harvesting: Autologous Skin Grafting without Donor-site Morbidity |
| Authors: |
Joshua Tam, PhD, Ying Wang, MD, William A. Farinelli, BA, Joel Jiménez-Lozano, PhD, Walfre Franco, PhD, Fernanda H. Sakamoto, MD, PhD, Evelyn J. Cheung, MD, Martin Purschke, PhD, Apostolos G. Doukas, PhD, R. Rox Anderson, MD |
| Source: |
Plastic and Reconstructive Surgery, Global Open, Vol 1, Iss 6, p e47 (2013) |
| Publisher Information: |
Wolters Kluwer, 2013. |
| Publication Year: |
2013 |
| Collection: |
LCC:Surgery |
| Subject Terms: |
Surgery, RD1-811 |
| More Details: |
Background: Conventional autologous skin grafts are associated with significant donor-site morbidity. This study was conducted to determine feasibility, safety, and efficacy of a new strategy for skin grafting based on harvesting small columns of full-thickness skin with minimal donor-site morbidity. Methods: The swine model was used for this study. Hundreds of full-thickness columns of skin tissue (~700 µm diameter) were harvested using a custom-made harvesting device, and then applied directly to excisional skin wounds. Healing in donor and graft sites was evaluated over 3 months by digital photographic measurement of wound size and blinded, computer-aided evaluation of histological features and compared with control wounds that healed by secondary intention or with conventional split-thickness skin grafts (STSG). Results: After harvesting hundreds of skin columns, the donor sites healed rapidly without scarring. These sites reepithelialized within days and were grossly and histologically indistinguishable from normal skin within 7 weeks. By contrast, STSG donor sites required 2 weeks for reepithelialization and retained scar-like characteristics in epidermal and dermal architecture throughout the experiment. Wounds grafted with skin columns resulted in accelerated reepithelialization compared with ungrafted wounds while avoiding the “fish-net” patterning caused by STSG. Conclusion: Full-thickness columns of skin can be harvested in large quantities with negligible long-term donor-site morbidity, and these columns can be applied directly to skin wounds to enhance wound healing. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2169-7574 |
| Relation: |
http://journals.lww.com/prsgo/Fulltext/2013/09000/Article.1.aspx; https://doaj.org/toc/2169-7574 |
| DOI: |
10.1097/GOX.0b013e3182a85a36 |
| Access URL: |
https://doaj.org/article/489865ff76fb44a3a605f42af45ef10f |
| Accession Number: |
edsdoj.489865ff76fb44a3a605f42af45ef10f |
| Database: |
Directory of Open Access Journals |
