| Title: |
Structure based docking and biological evaluation towards exploring potential anti-cancerous and apoptotic activity of 6-Gingerol against human prostate carcinoma cells |
| Authors: |
Habiba Khan, Iqbal Azad, Zeeshan Arif, Shama Parveen, Saurabh Kumar, Juhi Rais, Jamal Akhtar Ansari, Malik Nasibullah, Sudhir Kumar, Md Arshad |
| Source: |
BMC Complementary Medicine and Therapies, Vol 24, Iss 1, Pp 1-23 (2024) |
| Publisher Information: |
BMC, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Other systems of medicine |
| Subject Terms: |
Prostate cancer, Androgen receptor, 6-Gingerol, Molecular docking, Anticancer, Other systems of medicine, RZ201-999 |
| More Details: |
Abstract Background 6-Gingerol (6-G) is the primary active phytocomponent of ginger and has been shown to regulate multiple targets against cancer and its treatment. Androgen receptors (ARs) remain critical in the progression of prostate cancer (PCa). This study focuses on investigating 6-G as a promising anti-cancerous agent that inhibits AR activity significantly. Methods In this study, molecular docking simulation was done to investigate the binding affinity of 6-G and control drug Bicalutamide (BT) against oncogenic AR and tumor suppressor estrogen receptor β (ERβ). The crystal structure of AR and ERβ was retrieved from Protein Data Bank (PDB) and docked with 3D Pubchem structures of 6-G using iGEMDOCK and AutoDock. Further in vitro study was done to evaluate the antioxidant, anti-cancerous, apoptotic, and wound healing potential of 6-G. Results The result displays that 6-G shows good binding affinity with AR and ERβ. Condensation of the nucleus, change in mitochondrial membrane potential (MMP) and the ability to induce reactive oxygen species (ROS) were done in human PCa PC-3 cells. Results from the MTT assay demonstrated that 6-G and control drug BT showed significant (p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2662-7671 |
| Relation: |
https://doaj.org/toc/2662-7671 |
| DOI: |
10.1186/s12906-023-04269-1 |
| Access URL: |
https://doaj.org/article/4866121fa2b5441cb4506cda28c5270e |
| Accession Number: |
edsdoj.4866121fa2b5441cb4506cda28c5270e |
| Database: |
Directory of Open Access Journals |
