Bibliographic Details
| Title: |
Ginsenoside Rb1, salvianolic acid B and their combination modulate gut microbiota and improve glucolipid metabolism in high-fat diet induced obese mice |
| Authors: |
Ying Bai, Xueli Bao, Qianqian Mu, Xin Fang, Ruyuan Zhu, Chenyue Liu, Fangfang Mo, Dongwei Zhang, Guangjian Jiang, Ping Li, Sihua Gao, Dandan Zhao |
| Source: |
PeerJ, Vol 9, p e10598 (2021) |
| Publisher Information: |
PeerJ Inc., 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Medicine
LCC:Biology (General) |
| Subject Terms: |
Ginsenoside Rb1, Salvianolic acid B, Gut microbiota, Glucolipid metabolism, 16S rDNA sequencing, Medicine, Biology (General), QH301-705.5 |
| More Details: |
Background To observe the effect of ginsenoside Rb1, salvianolic acid B and their combination on glucolipid metabolism and structural changes of gut microbiota. Methods Eight-week-old C57BL/6J mice were fed 45% high-fat diet to induce obesity. The obese mice were randomly divided into four groups, Con group as model control, ginsenoside Rb1 (Rb1) group, salvianolic acid B (SalB) group and ginsenoside Rb1+ salvianolic acid B (Rb1SalB) group. Mice in Rb1, SalB and Rb1SalB group were treated by gavage with ginsenoside Rb1, salvianolic acid B and the combination of the two ingredients, respectively. While mice in Con group were given the same amount of sterile water. The intervention lasted 8 weeks. Body weight and fasting blood glucose were measured every 2 weeks. Oral glucose tolerance test was conducted on the 4th and 8th week of drug intervention. At the end of the experiment, total cholesterol, triglyceride, high density lipoprotein cholesterol, low density lipoprotein cholesterol and non-esterified fatty acid content as well as glycated hemoglobin were measured and feces were collected for 16S rDNA sequencing. Results Both ginsenoside Rb1 and Rb1SalB combination decreased body weight significantly (P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2167-8359 |
| Relation: |
https://peerj.com/articles/10598.pdf; https://peerj.com/articles/10598/; https://doaj.org/toc/2167-8359 |
| DOI: |
10.7717/peerj.10598 |
| Access URL: |
https://doaj.org/article/a4844d4351954a968aa057c446dee99c |
| Accession Number: |
edsdoj.4844d4351954a968aa057c446dee99c |
| Database: |
Directory of Open Access Journals |
