Genetic and Epigenetic Risk Factors for the Development of Simple Obesity in Children: a Literature Review
| Title: | Genetic and Epigenetic Risk Factors for the Development of Simple Obesity in Children: a Literature Review |
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| Authors: | Anvar A. Dzhumagaziev, Dina A. Bezrukova, Natalia M. Shilina, Natalia Yu. Otto, Ekaterina V. Sosinovskaya, A. V. Filipchuk |
| Source: | Педиатрическая фармакология, Vol 21, Iss 6, Pp 510-515 (2024) |
| Publisher Information: | Union of pediatricians of Russia, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Pediatrics LCC:Therapeutics. Pharmacology |
| Subject Terms: | children, overweight, obesity, risks, genetic factors, epigenetic factors, Pediatrics, RJ1-570, Therapeutics. Pharmacology, RM1-950 |
| More Details: | Childhood obesity can be persisted into adulthood with a significant degree of probability. The origins of childhood obesity are multifaceted and continue to be intensively studied. Its massive spread over the past decades is primarily due to a violation of the balance between incoming and outgoing energy. The combination of genetic and epigenetic factors that can influence the formation of obesity is an interesting and developing area of research. A systematic review of the literature for 2013–2023 was conducted using eLibrary and PubMed. It has been found that the increase in the prevalence of childhood obesity in recent decades is associated with changes in human lifestyle, which lead to epigenetic changes in the genome. Decoding the interaction of genes with the environment, along with an individual genotype, will allow personalized prediction of obesity associated with a specific genome, epigenome and lifestyle, and the development of targeted preventive measures starting from the antenatal age. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | Russian |
| ISSN: | 1727-5776 2500-3089 |
| Relation: | https://www.pedpharma.ru/jour/article/view/2552; https://doaj.org/toc/1727-5776; https://doaj.org/toc/2500-3089 |
| DOI: | 10.15690/pf.v21i6.2828 |
| Access URL: | https://doaj.org/article/483a2d4dd4de49d8918998072604c8ec |
| Accession Number: | edsdoj.483a2d4dd4de49d8918998072604c8ec |
| Database: | Directory of Open Access Journals |
| ISSN: | 17275776 25003089 |
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| DOI: | 10.15690/pf.v21i6.2828 |
| Published in: | Педиатрическая фармакология |
| Language: | Russian |