| Title: |
Type 1 diabetes, glycemic traits, and risk of dental caries: a Mendelian randomization study |
| Authors: |
Li Tan, Meng-Mei Zhong, Ya-Qiong Zhao, Jie Zhao, Marie Aimee Dusenge, Yao Feng, Qin Ye, Jing Hu, Ze-Yue Ou-Yang, Ning-Xin Chen, Xiao-Lin Su, Qian Zhang, Qiong Liu, Hui Yuan, Min-Yuan Wang, Yun-Zhi Feng, Yue Guo |
| Source: |
Frontiers in Genetics, Vol 14 (2023) |
| Publisher Information: |
Frontiers Media S.A., 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Genetics |
| Subject Terms: |
Mendelian randomization analysis, diabetes mellitus, type 1, glycemic traits, dental caries, multidisciplinary intervention, Genetics, QH426-470 |
| More Details: |
Background: Regarding past epidemiological studies, there has been disagreement over whether type 1 diabetes (T1DM) is one of the risk factors for dental caries. The purpose of this study was to determine the causative links between genetic susceptibility to T1DM, glycemic traits, and the risk of dental caries using Mendelian randomization (MR) approaches.Methods: Summary-level data were collected on genome-wide association studies (GWAS) of T1DM, fasting glucose (FG), glycated hemoglobin (HbA1c), fasting insulin (FI), and dental caries. MR was performed using the inverse-variance weighting (IVW) method, and sensitivity analyses were conducted using the MR-Egger method, weighted median, weighted mode, replication cohort, and multivariable MR conditioning on potential mediators.Results: The risk of dental caries increased as a result of genetic susceptibility to T1DM [odds ratio (OR) = 1.044; 95% confidence interval (CI) = 1.015–1.074; p = 0.003], with consistent findings in the replication cohort. The relationship between T1DM and dental caries was stable when adjusted for BMI, smoking, alcohol intake, and type 2 diabetes (T2DM) in multivariable MR. However, no significant correlations between the risk of dental caries and FG, HbA1c, or FI were found.Conclusion: These results indicate that T1DM has causal involvement in the genesis of dental caries. Therefore, periodic reinforcement of oral hygiene instructions must be added to the management and early multidisciplinary intervention of T1DM patients, especially among adolescents and teenagers, who are more susceptible to T1DM. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1664-8021 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fgene.2023.1230113/full; https://doaj.org/toc/1664-8021 |
| DOI: |
10.3389/fgene.2023.1230113 |
| Access URL: |
https://doaj.org/article/e47e162b373041a8bec2db83b26fa803 |
| Accession Number: |
edsdoj.47e162b373041a8bec2db83b26fa803 |
| Database: |
Directory of Open Access Journals |
