Bibliographic Details
| Title: |
Regulation of autophagy by VPS34 branched ubiquitination controls proteostasis and liver metabolism |
| Authors: |
Yu-Hsuan Chen, Ruey-Hwa Chen |
| Source: |
Molecular & Cellular Oncology, Vol 8, Iss 3 (2021) |
| Publisher Information: |
Taylor & Francis Group, 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Neoplasms. Tumors. Oncology. Including cancer and carcinogens |
| Subject Terms: |
autophagy, branched ubiquitination, vps34, liver steatosis, protein quality control, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282 |
| More Details: |
Ubiquitin-proteasome system and autophagy are the two major recycling processes. Our recent work uncovers a K29/K48 branched ubiquitination on the phosphatidylinositol 3-kinase catalytic subunit type 3 (PI3KC3, best known as VPS34). This ubiquitination is positively or negatively regulated under pathophysiological conditions to influence on autophagy, proteostasis and lipid homeostasis. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2372-3556
23723556 |
| Relation: |
https://doaj.org/toc/2372-3556 |
| DOI: |
10.1080/23723556.2021.1915076 |
| Access URL: |
https://doaj.org/article/47dabfef38e04489b6258a86e6c10b8a |
| Accession Number: |
edsdoj.47dabfef38e04489b6258a86e6c10b8a |
| Database: |
Directory of Open Access Journals |
