Bibliographic Details
| Title: |
Prevalence and characteristics of upfront diuretic resistance in acute heart failure: The P‐Value‐AHF study |
| Authors: |
Julia Baumberger, Sabine Dinges, Eleonora Lupi, Thomas Wolters, Melina Stüssi‐Helbling, Pietro E. Cippà, Antonio Bellasi, Lars C. Huber, Mattia Arrigo |
| Source: |
ESC Heart Failure, Vol 12, Iss 1, Pp 688-694 (2025) |
| Publisher Information: |
Wiley, 2025. |
| Publication Year: |
2025 |
| Collection: |
LCC:Diseases of the circulatory (Cardiovascular) system |
| Subject Terms: |
Acute heart failure, Decongestion, Diuresis, Diuretic resistance, Natriuresis, Diseases of the circulatory (Cardiovascular) system, RC666-701 |
| More Details: |
Abstract Aims Diuretic resistance (i.e., insufficient diuretic and natriuretic response to an appropriate dose of intravenously administered loop diuretic) is a major cause of insufficient decongestion in acute heart failure (AHF). Early assessment of diuretic and natriuretic response already after the first administration of loop diuretic is currently recommended, but few data exist on the prevalence and characteristics of upfront diuretic resistance in AHF. The aim of this sub‐study of the P‐Value‐AHF randomized clinical trial was to investigate the prevalence and characteristics of upfront diuretic resistance in patients presenting with AHF in the emergency department (ED). Methods Consecutive patients presenting with a clinical diagnosis of AHF, ≥1 sign of congestion, and NT‐proBNP >1000 ng/L between February and June 2024 were prospectively screened. Loop diuretics were administered per protocol: 40 mg furosemide i.v. in diuretic‐naïve patients and those on oral torasemide |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2055-5822 |
| Relation: |
https://doaj.org/toc/2055-5822 |
| DOI: |
10.1002/ehf2.15069 |
| Access URL: |
https://doaj.org/article/d4781fafb8744ab7923d86fa30d3ce73 |
| Accession Number: |
edsdoj.4781fafb8744ab7923d86fa30d3ce73 |
| Database: |
Directory of Open Access Journals |
