Academic Journal
Analysis of pathological and clinical characteristics of cervical conization according to age group in Japan
| Title: | Analysis of pathological and clinical characteristics of cervical conization according to age group in Japan |
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| Authors: | Isao Murakami, Akiko Ohno, Masae Ikeda, Hiroshi Yamashita, Mikio Mikami, Yoichi Kobayashi, Satoru Nagase, Masatoshi Yokoyama, Takayuki Enomoto, Hidetaka Katabuchi |
| Source: | Heliyon, Vol 6, Iss 10, Pp e05193- (2020) |
| Publisher Information: | Elsevier, 2020. |
| Publication Year: | 2020 |
| Collection: | LCC:Science (General) LCC:Social sciences (General) |
| Subject Terms: | Cancer research, Cancer surgery, Gynecology, Oncology, Clinical research, Cervical intraepithelial neoplasia, Science (General), Q1-390, Social sciences (General), H1-99 |
| More Details: | Objective: With increased screening, more patients with precancerous or early cervical cancer are now being identified. Age at pregnancy, and thus number of patients requiring fertility preservation, have also increased, resulting in more diagnostic and therapeutic cervical conization (conization) procedures. We here investigated the pathological and clinical characteristics of patients undergoing conization, with a focus on age. The objectives of our study were to identify the risk factors potentially involved in cervical intraepithelial neoplasia (CIN) recurrence or persistence, additional treatment after conization, the effects of conization on pregnancy, and the actual status of conization in Japan. Study design: A “Subcommittee for Investigation of Cervical Conization” within the Gynecologic Oncology Committee in the Japan Society of Obstetrics and Gynecology investigated pathological and clinical characteristics of conization at 205 institutions in Japan. We analyzed pathological and clinical characteristics according to age ≤50 and >50 years. Results: Patients aged 20–40 years accounted for 12904 (87%) of the 14,832 study patients (median: 37 years, range: 16–88 years). However, 1838 (12.4%) were aged >50 years. The commonest post-operative diagnosis was CIN grade 3 in all age groups. Rates of invasive cancer, post-operative detection of more advanced lesions, positive surgical margins, additional treatment, and recurrence were significantly higher in patients aged ≥50 years than those aged |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2405-8440 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2405844020320363; https://doaj.org/toc/2405-8440 |
| DOI: | 10.1016/j.heliyon.2020.e05193 |
| Access URL: | https://doaj.org/article/d476b2cacfd148cc8de29e5e415da121 |
| Accession Number: | edsdoj.476b2cacfd148cc8de29e5e415da121 |
| Database: | Directory of Open Access Journals |
| ISSN: | 24058440 |
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| DOI: | 10.1016/j.heliyon.2020.e05193 |
| Published in: | Heliyon |
| Language: | English |