Association of endothelial function and limb artery indices with coronary artery stenosis severity in patients with hypertension
| Title: | Association of endothelial function and limb artery indices with coronary artery stenosis severity in patients with hypertension |
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| Authors: | Shiyi Tao, Lintong Yu, Deshuang Yang, Li Huang, Jun Li |
| Source: | Annals of Medicine, Vol 56, Iss 1 (2024) |
| Publisher Information: | Taylor & Francis Group, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Medicine |
| Subject Terms: | Hypertension, coronary artery stenosis, endothelial function, peripheral arterial disease, risk factor, Medicine |
| More Details: | Background Hypertension is one of the major risk factors for cardiovascular events. This study aims to analyse the association of endothelial function and limb artery indices with coronary artery stenosis (CAS) severity in hypertension based on easily accessible and detailed clinical information, and to help accurately identify high-risk groups and avoid missed diagnosis and misdiagnosis.Methods Admission data of 1,375 consecutive hypertensive patients complicated with suspected coronary atherosclerotic heart disease (CHD) from September 2020 to August 2021 in China-Japan Friendship Hospital were retrospectively assessed. All candidates underwent coronary angiography for screening. A total of 600 eligible patients were classified in the CHD group (n = 359) and non-CHD group (n = 241) based on their coronary angiography results. Subjects in the CHD group were further assigned to ‘high stenosis’ (n = 178) and ‘low stenosis’ (n = 181) subgroups based on the median value of Gensini score. Endothelial function and limb artery indicators, including brachial artery flow-mediated vasodilatation (FMD), ankle-brachial index (ABI) and brachial-ankle pulse velocity (baPWV), were examined and compared between subgroups. Multivariate logistic regression analysis and multiple linear regression analysis were carried out to select independent risk factors of CAS severity in hypertension. A predictive equation was conducted according to the results of multivariate logistic regression analysis to make clinical practice easier. As the receiver operating characteristic (ROC) curve had been plotted, the predictive ability of endothelial function and limb artery indicators in CAS severity in hypertension was detected by the area under the curve (AUC).Results In patients with hypertension, the FMD (p = 0.023), ABI (p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 07853890 1365-2060 0785-3890 |
| Relation: | https://doaj.org/toc/0785-3890; https://doaj.org/toc/1365-2060 |
| DOI: | 10.1080/07853890.2024.2427369 |
| Access URL: | https://doaj.org/article/c4767fb239114a6f8418720db8302d51 |
| Accession Number: | edsdoj.4767fb239114a6f8418720db8302d51 |
| Database: | Directory of Open Access Journals |
| ISSN: | 07853890 13652060 |
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| DOI: | 10.1080/07853890.2024.2427369 |
| Published in: | Annals of Medicine |
| Language: | English |