Bibliographic Details
| Title: |
Long-Term Antibody Response against SARS-CoV-2 in Health Care Workers: Effectiveness of Homologous and Heterologous Regimens and Their Relation to Systemic Vaccine-Associated Symptoms |
| Authors: |
Helene Kierkegaard, Birgit Thorup Røge, Amanda Nissen, Jonna Skov Madsen |
| Source: |
Vaccines, Vol 10, Iss 10, p 1599 (2022) |
| Publisher Information: |
MDPI AG, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Medicine |
| Subject Terms: |
COVID-19 vaccines, vaccine effectiveness, BNT162b2 vaccine, mRNA-1273 vaccine, ChAdOx1 vaccine, 19 Elecsys Anti-SARS-CoV-2 S assay, Medicine |
| More Details: |
This prospective study provides data on the long-term humoral immunogenicity of a heterologous off-label vaccine regimen combining the adenoviral-vectored ChAdOx1 nCoV-19 from Astra-Zeneca (ChAd) with the mRNA-1273 vaccine from Moderna (m1273) in comparison with two different homologous mRNA vaccine schedules. Of the 316 COVID-19 naïve adult health care workers (HCW) included to complete a survey on vaccine-associated symptoms (VAS), 197 had received the homologous BNT162b2 mRNA vaccine from Pfizer/BioNTech (BNT/BNT), 76 the homologous m1273/m1273, and 43 the heterologous ChAd/m1273 vaccine regimen. The concentration of antibodies against SARS-CoV-2 spike protein in plasma 5–7 months after the second vaccine dose was higher in the m1273/m1273 and ChAd/m1273 than the BNT/BNT vaccine group. The frequency of systemic VAS after the first vaccine dose was 86% after ChAd compared with 35% and 39% after BNT and m1273, respectively (p < 0.0001), and after the second vaccine dose, the highest (89%) in the m1273/m1273 group (p < 0.001). Individuals with systemic VAS achieved higher levels of antibodies irrespective of vaccine regimen. In conclusion, VAS serve as a strong predictor of long-term humoral immune response, and the heterologous ChAd/m1273 vaccine regimen provides an at least equal long-term humoral immune response compared with the standard vaccine regimens used in Denmark. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2076-393X |
| Relation: |
https://www.mdpi.com/2076-393X/10/10/1599; https://doaj.org/toc/2076-393X |
| DOI: |
10.3390/vaccines10101599 |
| Access URL: |
https://doaj.org/article/473ce2e38ff145ec9d9dbb9f631bb8df |
| Accession Number: |
edsdoj.473ce2e38ff145ec9d9dbb9f631bb8df |
| Database: |
Directory of Open Access Journals |
