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Enhanced systemic oxidative stress response in patients with idiopathic inflammatory myopathies

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Title: Enhanced systemic oxidative stress response in patients with idiopathic inflammatory myopathies
Authors: Anna Mikołajczyk-Korona, Radosław Dziedzic, Krzysztof Wójcik, Magdalena Olchawa, Tadeusz Sarna, Jakub Pięta, Bogdan Jakiela, Lech Zaręba, Jan G. Bazan, Daniel P. Potaczek, Joanna Kosałka-Węgiel, Mateusz Socha, Piotr Kuszmiersz, Agnieszka Padjas, Stanisława Bazan-Socha
Source: Arthritis Research & Therapy, Vol 27, Iss 1, Pp 1-13 (2025)
Publisher Information: BMC, 2025.
Publication Year: 2025
Collection: LCC:Diseases of the musculoskeletal system
Subject Terms: Dermatomyositis, Myositis, Idiopathic inflammatory myopathies, Oxidative stress, Coumarin boronic acid assay, Diseases of the musculoskeletal system, RC925-935
More Details: Abstract Background Idiopathic inflammatory myopathies (IIM) are characterized by chronic inflammation, endothelial dysfunction, and muscle tissue mitochondrial defect, leading to the local oxidative stress response. However, data on its systemic intensity and correlation with IIM clinical and laboratory characteristics remains scarce. Methods In clinically stable dermatomyositis (n = 18) and myositis (n = 38) patients and matched controls (n = 50), we measured global oxidative stress response in peripheral blood using a novel coumarin boronic acid (CBA) assay enabling real-time detection of protein hydroperoxides (HP) formed in serum. Results We documented 36% faster kinetics (p
Document Type: article
File Description: electronic resource
Language: English
ISSN: 1478-6362
Relation: https://doaj.org/toc/1478-6362
DOI: 10.1186/s13075-025-03511-0
Access URL: https://doaj.org/article/47255537a2a54ca18931e05d896190a1
Accession Number: edsdoj.47255537a2a54ca18931e05d896190a1
Database: Directory of Open Access Journals
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  Data: Enhanced systemic oxidative stress response in patients with idiopathic inflammatory myopathies
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  Data: <searchLink fieldCode="AR" term="%22Anna+Mikołajczyk-Korona%22">Anna Mikołajczyk-Korona</searchLink><br /><searchLink fieldCode="AR" term="%22Radosław+Dziedzic%22">Radosław Dziedzic</searchLink><br /><searchLink fieldCode="AR" term="%22Krzysztof+Wójcik%22">Krzysztof Wójcik</searchLink><br /><searchLink fieldCode="AR" term="%22Magdalena+Olchawa%22">Magdalena Olchawa</searchLink><br /><searchLink fieldCode="AR" term="%22Tadeusz+Sarna%22">Tadeusz Sarna</searchLink><br /><searchLink fieldCode="AR" term="%22Jakub+Pięta%22">Jakub Pięta</searchLink><br /><searchLink fieldCode="AR" term="%22Bogdan+Jakiela%22">Bogdan Jakiela</searchLink><br /><searchLink fieldCode="AR" term="%22Lech+Zaręba%22">Lech Zaręba</searchLink><br /><searchLink fieldCode="AR" term="%22Jan+G%2E+Bazan%22">Jan G. Bazan</searchLink><br /><searchLink fieldCode="AR" term="%22Daniel+P%2E+Potaczek%22">Daniel P. Potaczek</searchLink><br /><searchLink fieldCode="AR" term="%22Joanna+Kosałka-Węgiel%22">Joanna Kosałka-Węgiel</searchLink><br /><searchLink fieldCode="AR" term="%22Mateusz+Socha%22">Mateusz Socha</searchLink><br /><searchLink fieldCode="AR" term="%22Piotr+Kuszmiersz%22">Piotr Kuszmiersz</searchLink><br /><searchLink fieldCode="AR" term="%22Agnieszka+Padjas%22">Agnieszka Padjas</searchLink><br /><searchLink fieldCode="AR" term="%22Stanisława+Bazan-Socha%22">Stanisława Bazan-Socha</searchLink>
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  Data: Arthritis Research & Therapy, Vol 27, Iss 1, Pp 1-13 (2025)
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  Data: BMC, 2025.
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  Data: <searchLink fieldCode="DE" term="%22Dermatomyositis%22">Dermatomyositis</searchLink><br /><searchLink fieldCode="DE" term="%22Myositis%22">Myositis</searchLink><br /><searchLink fieldCode="DE" term="%22Idiopathic+inflammatory+myopathies%22">Idiopathic inflammatory myopathies</searchLink><br /><searchLink fieldCode="DE" term="%22Oxidative+stress%22">Oxidative stress</searchLink><br /><searchLink fieldCode="DE" term="%22Coumarin+boronic+acid+assay%22">Coumarin boronic acid assay</searchLink><br /><searchLink fieldCode="DE" term="%22Diseases+of+the+musculoskeletal+system%22">Diseases of the musculoskeletal system</searchLink><br /><searchLink fieldCode="DE" term="%22RC925-935%22">RC925-935</searchLink>
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  Data: Abstract Background Idiopathic inflammatory myopathies (IIM) are characterized by chronic inflammation, endothelial dysfunction, and muscle tissue mitochondrial defect, leading to the local oxidative stress response. However, data on its systemic intensity and correlation with IIM clinical and laboratory characteristics remains scarce. Methods In clinically stable dermatomyositis (n = 18) and myositis (n = 38) patients and matched controls (n = 50), we measured global oxidative stress response in peripheral blood using a novel coumarin boronic acid (CBA) assay enabling real-time detection of protein hydroperoxides (HP) formed in serum. Results We documented 36% faster kinetics (p
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      – SubjectFull: Dermatomyositis
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      – SubjectFull: Myositis
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