Bibliographic Details
| Title: |
Enhanced systemic oxidative stress response in patients with idiopathic inflammatory myopathies |
| Authors: |
Anna Mikołajczyk-Korona, Radosław Dziedzic, Krzysztof Wójcik, Magdalena Olchawa, Tadeusz Sarna, Jakub Pięta, Bogdan Jakiela, Lech Zaręba, Jan G. Bazan, Daniel P. Potaczek, Joanna Kosałka-Węgiel, Mateusz Socha, Piotr Kuszmiersz, Agnieszka Padjas, Stanisława Bazan-Socha |
| Source: |
Arthritis Research & Therapy, Vol 27, Iss 1, Pp 1-13 (2025) |
| Publisher Information: |
BMC, 2025. |
| Publication Year: |
2025 |
| Collection: |
LCC:Diseases of the musculoskeletal system |
| Subject Terms: |
Dermatomyositis, Myositis, Idiopathic inflammatory myopathies, Oxidative stress, Coumarin boronic acid assay, Diseases of the musculoskeletal system, RC925-935 |
| More Details: |
Abstract Background Idiopathic inflammatory myopathies (IIM) are characterized by chronic inflammation, endothelial dysfunction, and muscle tissue mitochondrial defect, leading to the local oxidative stress response. However, data on its systemic intensity and correlation with IIM clinical and laboratory characteristics remains scarce. Methods In clinically stable dermatomyositis (n = 18) and myositis (n = 38) patients and matched controls (n = 50), we measured global oxidative stress response in peripheral blood using a novel coumarin boronic acid (CBA) assay enabling real-time detection of protein hydroperoxides (HP) formed in serum. Results We documented 36% faster kinetics (p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1478-6362 |
| Relation: |
https://doaj.org/toc/1478-6362 |
| DOI: |
10.1186/s13075-025-03511-0 |
| Access URL: |
https://doaj.org/article/47255537a2a54ca18931e05d896190a1 |
| Accession Number: |
edsdoj.47255537a2a54ca18931e05d896190a1 |
| Database: |
Directory of Open Access Journals |
