Bibliographic Details
| Title: |
A Stealthiness Evaluation of Main Chain Carboxybetaine Polymer Modified into Liposome |
| Authors: |
Mazaya Najmina, Shingo Kobayashi, Rena Shimazui, Haruka Takata, Mayuka Shibata, Kenta Ishibashi, Hiroshi Kamizawa, Akihiro Kishimura, Yoshihito Shiota, Daichi Ida, Taro Shimizu, Tatsuhiro Ishida, Yoshiki Katayama, Masaru Tanaka, Takeshi Mori |
| Source: |
Pharmaceutics, Vol 16, Iss 10, p 1271 (2024) |
| Publisher Information: |
MDPI AG, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Pharmacy and materia medica |
| Subject Terms: |
zwitterionic polymer, carboxybetaine, non-fouling polymer, liposome, Pharmacy and materia medica, RS1-441 |
| More Details: |
Background: Acrylamide polymers with zwitterionic carboxybetaine (CB) side groups have attracted attention as stealth polymers that do not induce antibodies when conjugated to proteins. However, they induce antibodies when modified onto liposomes. We hypothesized that antibodies are produced against polymer backbones rather than CB side groups. Objectives: In this study, we designed and synthesized a polymer employing CB in its main chain, poly(N-acetic acid-N-methyl-propyleneimine) (PAMPI), and evaluated the blood retention of PAMPI-modified liposomes in mice. Results: The non-fouling nature of PAMPI-modified liposomes estimated from serum protein adsorption was found to be not inferior to PCB- and PEG-modified liposomes. However, to our surprise, the PAMPI-modified liposomes showed an instantaneous clearance less than 1 h post-injection, comparable to the naked liposomes. Conclusions: The extent of the blood retention of polymer-modified liposomes cannot be predicted by their susceptibility to serum protein adsorption and semi-flexible conformation. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1999-4923 |
| Relation: |
https://www.mdpi.com/1999-4923/16/10/1271; https://doaj.org/toc/1999-4923 |
| DOI: |
10.3390/pharmaceutics16101271 |
| Access URL: |
https://doaj.org/article/4643eafd97b5426cbcfc0b614064954f |
| Accession Number: |
edsdoj.4643eafd97b5426cbcfc0b614064954f |
| Database: |
Directory of Open Access Journals |
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