Academic Journal
Data on the evaluation of the relation between β-arrestin 2 and YAP phosphorylation in patient-derived colon cancer organoids
| Title: | Data on the evaluation of the relation between β-arrestin 2 and YAP phosphorylation in patient-derived colon cancer organoids |
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| Authors: | Minsuh Kim, Ji Min Kim, Eun Jeong Cho, Chang Ohk Sung, Joon Kim, Se Jin Jang |
| Source: | Data in Brief, Vol 44, Iss , Pp 108506- (2022) |
| Publisher Information: | Elsevier, 2022. |
| Publication Year: | 2022 |
| Collection: | LCC:Computer applications to medicine. Medical informatics LCC:Science (General) |
| Subject Terms: | β-arrestin 2, Yes-associated protein (YAP), Hippo pathway, Cancer organoid, Patient-derived model, Computer applications to medicine. Medical informatics, R858-859.7, Science (General), Q1-390 |
| More Details: | The data presented in this article is related to a rapid communication entitled “β-arrestin 2 suppresses the activation of YAP by promoting LATS kinase activity”. This article describes the correlation of β-arrestin 2 and YAP phosphorylation in patient-derived organoid models. Here, we analyzed 45 colon cancer organoids (CCOs) selected in the related research article to investigate the role of β-arrestin 2 in YAP phosphorylation. Hematoxylin and eosin (H&E) staining and immunohistochemistry data showed that the CCOs maintained tissue architecture and histological features of their original cancer tissues. Moreover, mutation data detected from RNA-seq (RNA-sequencing) analysis showed that these CCOs retained the genetic features of their original colon cancer tissues as well. We also confirmed at the protein level that organoids expressing β-arrestin 2 showed high expression of phosphorylated YAP. These organoid model studies strongly support the related research article that β-arrestin 2 suppresses the activation of YAP in colon cancer. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2352-3409 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2352340922007004; https://doaj.org/toc/2352-3409 |
| DOI: | 10.1016/j.dib.2022.108506 |
| Access URL: | https://doaj.org/article/45da6c5b3d634aabab25753595b45f23 |
| Accession Number: | edsdoj.45da6c5b3d634aabab25753595b45f23 |
| Database: | Directory of Open Access Journals |
| ISSN: | 23523409 |
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| DOI: | 10.1016/j.dib.2022.108506 |
| Published in: | Data in Brief |
| Language: | English |