Bibliographic Details
| Title: |
TLR2/NF-κB signaling in macrophage/microglia mediated COVID-pain induced by SARS-CoV-2 envelope protein |
| Authors: |
Huan Cui, Fengrun Sun, Ning Yu, Yan Cao, Xue Wang, Di Zhang, Zhen Chen, Naili Wang, Bo Yuan, Penghao Liu, Wanru Duan, Wenying Qiu, Xiangsha Yin, Chao Ma |
| Source: |
iScience, Vol 27, Iss 10, Pp 111027- (2024) |
| Publisher Information: |
Elsevier, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Science |
| Subject Terms: |
Health sciences, Sensory neuroscience, Immune response, Cell biology, Science |
| More Details: |
Summary: Pain has become a major symptom of long COVID-19 without effective therapy. Apart from viral infection pathological process, SARS-CoV-2 membranal proteins (envelope [S2E], spike [S2S] and membrane [S2M]) also present pro-inflammatory feature independently. Here, we aim to uncover the neuroinflammatory mechanism of COVID-pain induced by SARS-CoV-2 membranal proteins. We detected the three proteins in both peripheral sensory ganglions and spinal dorsal horn of COVID-19 donors. After intradermal and intrathecal injection, only S2E triggered pain behaviors, accompanied with upregulated-phosphorylation nuclear factor kappa B (NF-κB), which was significantly attenuated by minocycline in mice. We further identified Toll-like receptor 2 (TLR2) among TLRs as the target of S2E to evoke inflammatory responses leading to COVID-pain. This study identified the nociceptive effect of S2E through directly interacting with macrophage/microglia TLR2 and inducing the following NF-κB inflammatory storm. Clearing away S2E and inhibiting macrophage/microglia TLR2 served as perspective therapeutic strategies for COVID-19 pain. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2589-0042 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2589004224022521; https://doaj.org/toc/2589-0042 |
| DOI: |
10.1016/j.isci.2024.111027 |
| Access URL: |
https://doaj.org/article/c45ce8a5654b46d58ce672e150b5244d |
| Accession Number: |
edsdoj.45ce8a5654b46d58ce672e150b5244d |
| Database: |
Directory of Open Access Journals |
