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Growth inhibition of cultured cancer cells by Ribes nigrum leaf extract

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Title: Growth inhibition of cultured cancer cells by Ribes nigrum leaf extract
Authors: Mikayel Ginovyan, Agnieszka Bartoszek, Izabela Koss-Mikołajczyk, Barbara Kusznierewicz, Pierre Andreoletti, Mustapha Cherkaoui-Malki, Naira Sahakyan
Source: AIMS Biophysics, Vol 9, Iss 3, Pp 282-293 (2022)
Publisher Information: AIMS Press, 2022.
Publication Year: 2022
Collection: LCC:Biology (General)
LCC:Biotechnology
Subject Terms: plant extract, armenian flora, cytotoxicity, microglia, human adenocarcinoma, breast cancer, Biology (General), QH301-705.5, Biotechnology, TP248.13-248.65
More Details: The present article includes data on the possible selective cytotoxic effect of extract of Ribes nigrum L. growing at high Armenian landscape. For this purpose, different non-cancer (microglial BV-2 wild type (Wt), acyl-CoA oxidase 1 (ACOX1) deficient (Acox1−/−) and cancer (human colon adenocarcinoma HT29 and human breast cancer MCF7) cell lines were applied. R. nigrum leaf ethanol extract showed a growth inhibition effect towards HT29 and MCF7 cells started from 6 h of treatment at the concentration of 0.5 mg/mL DW. The lowest concentration (0.125 mg/mL DW) of the investigated extract expressed cytotoxicity after 72 hours following cancer cell treatment. In contrast to the cancer cells, in the case of the tested non-cancer cells, cytotoxic effect was not observed at the applied concentrations. The extract sub-cytotoxic concentration, in this case, was reported to be the 1 mg/mL DW. Further investigations are needed to confirm the selective cytotoxicity and possible action mechanisms of the leaf extract of R. nigrum.
Document Type: article
File Description: electronic resource
Language: English
ISSN: 2377-9098
Relation: https://doaj.org/toc/2377-9098
DOI: 10.3934/biophy.2022024?viewType=HTML
DOI: 10.3934/biophy.2022024
Access URL: https://doaj.org/article/ee455e5e3e224717ac09f07c1599fb5c
Accession Number: edsdoj.455e5e3e224717ac09f07c1599fb5c
Database: Directory of Open Access Journals
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  Data: Growth inhibition of cultured cancer cells by Ribes nigrum leaf extract
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  Data: <searchLink fieldCode="AR" term="%22Mikayel+Ginovyan%22">Mikayel Ginovyan</searchLink><br /><searchLink fieldCode="AR" term="%22Agnieszka+Bartoszek%22">Agnieszka Bartoszek</searchLink><br /><searchLink fieldCode="AR" term="%22Izabela+Koss-Mikołajczyk%22">Izabela Koss-Mikołajczyk</searchLink><br /><searchLink fieldCode="AR" term="%22Barbara+Kusznierewicz%22">Barbara Kusznierewicz</searchLink><br /><searchLink fieldCode="AR" term="%22Pierre+Andreoletti%22">Pierre Andreoletti</searchLink><br /><searchLink fieldCode="AR" term="%22Mustapha+Cherkaoui-Malki%22">Mustapha Cherkaoui-Malki</searchLink><br /><searchLink fieldCode="AR" term="%22Naira+Sahakyan%22">Naira Sahakyan</searchLink>
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  Data: AIMS Biophysics, Vol 9, Iss 3, Pp 282-293 (2022)
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  Data: <searchLink fieldCode="DE" term="%22plant+extract%22">plant extract</searchLink><br /><searchLink fieldCode="DE" term="%22armenian+flora%22">armenian flora</searchLink><br /><searchLink fieldCode="DE" term="%22cytotoxicity%22">cytotoxicity</searchLink><br /><searchLink fieldCode="DE" term="%22microglia%22">microglia</searchLink><br /><searchLink fieldCode="DE" term="%22human+adenocarcinoma%22">human adenocarcinoma</searchLink><br /><searchLink fieldCode="DE" term="%22breast+cancer%22">breast cancer</searchLink><br /><searchLink fieldCode="DE" term="%22Biology+%28General%29%22">Biology (General)</searchLink><br /><searchLink fieldCode="DE" term="%22QH301-705%2E5%22">QH301-705.5</searchLink><br /><searchLink fieldCode="DE" term="%22Biotechnology%22">Biotechnology</searchLink><br /><searchLink fieldCode="DE" term="%22TP248%2E13-248%2E65%22">TP248.13-248.65</searchLink>
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  Data: The present article includes data on the possible selective cytotoxic effect of extract of Ribes nigrum L. growing at high Armenian landscape. For this purpose, different non-cancer (microglial BV-2 wild type (Wt), acyl-CoA oxidase 1 (ACOX1) deficient (Acox1−/−) and cancer (human colon adenocarcinoma HT29 and human breast cancer MCF7) cell lines were applied. R. nigrum leaf ethanol extract showed a growth inhibition effect towards HT29 and MCF7 cells started from 6 h of treatment at the concentration of 0.5 mg/mL DW. The lowest concentration (0.125 mg/mL DW) of the investigated extract expressed cytotoxicity after 72 hours following cancer cell treatment. In contrast to the cancer cells, in the case of the tested non-cancer cells, cytotoxic effect was not observed at the applied concentrations. The extract sub-cytotoxic concentration, in this case, was reported to be the 1 mg/mL DW. Further investigations are needed to confirm the selective cytotoxicity and possible action mechanisms of the leaf extract of R. nigrum.
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        PageCount: 12
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      – SubjectFull: plant extract
        Type: general
      – SubjectFull: armenian flora
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      – SubjectFull: cytotoxicity
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      – TitleFull: Growth inhibition of cultured cancer cells by Ribes nigrum leaf extract
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