Bibliographic Details
| Title: |
Growth inhibition of cultured cancer cells by Ribes nigrum leaf extract |
| Authors: |
Mikayel Ginovyan, Agnieszka Bartoszek, Izabela Koss-Mikołajczyk, Barbara Kusznierewicz, Pierre Andreoletti, Mustapha Cherkaoui-Malki, Naira Sahakyan |
| Source: |
AIMS Biophysics, Vol 9, Iss 3, Pp 282-293 (2022) |
| Publisher Information: |
AIMS Press, 2022. |
| Publication Year: |
2022 |
| Collection: |
LCC:Biology (General)
LCC:Biotechnology |
| Subject Terms: |
plant extract, armenian flora, cytotoxicity, microglia, human adenocarcinoma, breast cancer, Biology (General), QH301-705.5, Biotechnology, TP248.13-248.65 |
| More Details: |
The present article includes data on the possible selective cytotoxic effect of extract of Ribes nigrum L. growing at high Armenian landscape. For this purpose, different non-cancer (microglial BV-2 wild type (Wt), acyl-CoA oxidase 1 (ACOX1) deficient (Acox1−/−) and cancer (human colon adenocarcinoma HT29 and human breast cancer MCF7) cell lines were applied. R. nigrum leaf ethanol extract showed a growth inhibition effect towards HT29 and MCF7 cells started from 6 h of treatment at the concentration of 0.5 mg/mL DW. The lowest concentration (0.125 mg/mL DW) of the investigated extract expressed cytotoxicity after 72 hours following cancer cell treatment. In contrast to the cancer cells, in the case of the tested non-cancer cells, cytotoxic effect was not observed at the applied concentrations. The extract sub-cytotoxic concentration, in this case, was reported to be the 1 mg/mL DW. Further investigations are needed to confirm the selective cytotoxicity and possible action mechanisms of the leaf extract of R. nigrum. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2377-9098 |
| Relation: |
https://doaj.org/toc/2377-9098 |
| DOI: |
10.3934/biophy.2022024?viewType=HTML |
| DOI: |
10.3934/biophy.2022024 |
| Access URL: |
https://doaj.org/article/ee455e5e3e224717ac09f07c1599fb5c |
| Accession Number: |
edsdoj.455e5e3e224717ac09f07c1599fb5c |
| Database: |
Directory of Open Access Journals |
