Bibliographic Details
| Title: |
Normative Observational Nerve Ultrasound Values in School-Age Children and Adolescents and Their Application to Hereditary Neuropathies |
| Authors: |
Anna-Sophie Grimm, Charlotte Schubert, Alexander Grimm, Jan-Hendrik Stahl, Hanna Küpper, Veronka Horber, Josua Kegele, Sophia Willikens, Julia Wittlinger, Lina Serna-Higuita, Natalie Winter, Samuel Groeschel |
| Source: |
Frontiers in Neurology, Vol 11 (2020) |
| Publisher Information: |
Frontiers Media S.A., 2020. |
| Publication Year: |
2020 |
| Collection: |
LCC:Neurology. Diseases of the nervous system |
| Subject Terms: |
nerve ultrasound, children neuropathy, reference values, lysosomal storage diseases, nerve imaging, Neurology. Diseases of the nervous system, RC346-429 |
| More Details: |
Backgrounds: We have aimed to establish nerve ultrasound reference data in 8 to 17-year-old children and adolescents and to compare those data to younger children, adults, and age-matched children with polyneuropathies.Methods: High-resolution ultrasounds of the nerves were performed in 117 healthy children and adolescents at 20 predefined landmarks in the neck and the extremities of both sides. Mean values, side-to-side differences and intraneural ratios, as well as upper limits have been calculated. In a second step, a comparison between 25 children and adolescents of the same age range with proven hereditary and acquired neuropathies and lysosomal storage diseases has been carried out.Results: Nerve growth correlates significantly with age and reaches adult values at the age of around 15 years. The influence of body mass index and gender is negligible at most segments. By the use of age-specific upper limits, nerve enlargement could be seen in distinct types of neuropathies, particularly in demyelinating hereditary and inflammatory types, which is comparable to findings in adults, but also in rare lysosomal storage diseases.Conclusion: Nerve size correlates with age during childhood and reaches a climax in younger adults. Age-matched reference data are inevitable to differ between hypertrophic and non-hypertrophic nerve damage, e.g., in neuropathies. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1664-2295 |
| Relation: |
https://www.frontiersin.org/article/10.3389/fneur.2020.00303/full; https://doaj.org/toc/1664-2295 |
| DOI: |
10.3389/fneur.2020.00303 |
| Access URL: |
https://doaj.org/article/4520057ad8c04a0ba36b3c8de04b8fd0 |
| Accession Number: |
edsdoj.4520057ad8c04a0ba36b3c8de04b8fd0 |
| Database: |
Directory of Open Access Journals |
