Overexpression of GLI1 and PTTG1 as Poor Prognostic Factor of Patients with Laryngeal Squamous Cell Carcinoma
| Title: | Overexpression of GLI1 and PTTG1 as Poor Prognostic Factor of Patients with Laryngeal Squamous Cell Carcinoma |
|---|---|
| Authors: | Asmaa M. Ahmed, Mohamed Modather Aboshanif, Mohamed Omar A. Gad, Maha Salah El-Naggar, Doaa A. Gamal, Mayada F. Sedik, Heba E.M. El-Deek |
| Source: | SVU - International Journal of Medical Sciences, Vol 7, Iss 2, Pp 350-365 (2024) |
| Publisher Information: | South Valley University, Faculty of Medicine, 2024. |
| Publication Year: | 2024 |
| Collection: | LCC:Medicine |
| Subject Terms: | gli1 pttg1, laryngeal squamous cell carcinoma survival, Medicine |
| More Details: | Background: Laryngeal squamous cell carcinoma (LSCC) constitutes about 98% of all laryngeal carcinomas with high mortality rates. The transcription factors Glioma-associated oncogene homolog1 (GLI1) and pituitary tumor transforming gene-1 (PTTG1) were associated with poor prognosis in several carcinomas. To date, no previous studies addressed the role of GLI1 in LSCC and limited studies have examined the role of PTTG1 in LSCC. Objectives: This study aims to evaluate the immunohistochemical (IHC) expression of GLI1 and PTTG1 in LSCC, to correlate their expression with clinicopathological features and patients' survival, and to assess the correlation between both proteins in LSCC. Materials and methods: GLI1 and PTTG1 expression was immunohistochemically examined in 60 LSCC specimens and 50 benign vocal fold polyps (control group). Results: GLI1and PTTG1 expression were significantly higher in LSCC than in the control group (p |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2735-427X 2636-3402 |
| Relation: | https://svuijm.journals.ekb.eg/article_374347.html; https://doaj.org/toc/2735-427X; https://doaj.org/toc/2636-3402 |
| DOI: | 10.21608/svuijm.2024.303883.1927 |
| Access URL: | https://doaj.org/article/447eb46bc21e4c4d80e77bfed682a8c0 |
| Accession Number: | edsdoj.447eb46bc21e4c4d80e77bfed682a8c0 |
| Database: | Directory of Open Access Journals |
| ISSN: | 2735427X 26363402 |
|---|---|
| DOI: | 10.21608/svuijm.2024.303883.1927 |
| Published in: | SVU - International Journal of Medical Sciences |
| Language: | English |