Haploidentical hematopoietic stem cell transplantation in a myelofibrosis patient with primary graft failure
| Title: | Haploidentical hematopoietic stem cell transplantation in a myelofibrosis patient with primary graft failure |
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| Authors: | Cristina Tecchio, Angelo Andreini, Claudio Costantini, Alberto Zamò, Donata de Sabata, Fiorenza Aprili, Roberta Galavotti, Emanuele Guardalben, Fabio Benedetti |
| Source: | Hematology Reports, Vol 9, Iss 4 (2018) |
| Publisher Information: | MDPI AG, 2018. |
| Publication Year: | 2018 |
| Collection: | LCC:Diseases of the blood and blood-forming organs |
| Subject Terms: | primary graft failure, haploidentical hematopoietic stem cell transplantation, myelofibrosis, Diseases of the blood and blood-forming organs, RC633-647.5 |
| More Details: | The prognosis of patients affected by myelofibrosis (MF) is usually dismal and allogeneic hematopoietic stem cell transplantation (HSCT) remains the only cure. The number of HSCTs in MF patients has recently increased. However, a major obstacle is still represented by primary graft failure (PGF). Currently there are no definitive guidelines for the treatment of PGF and a second HSCT can be performed only when an allogeneic donor is rapidly available. Herein we report on a MF patient with PGF after an unrelated HSCT, who was rescued by a non-myeloablative, unmanipulated, haploidentical HSCT that resulted in persistent engraftment and bone-marrow fibrosis regression, but not in a long-term disease control. Based on this experience we briefly review the role of different conditioning regimens and hematopoietic stem cell sources in the setting of HSCT for MF patients with PGF. The role of haploidentical donors in MF patients lacking HLAmatched relatives is also discussed. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2038-8322 2038-8330 |
| Relation: | http://www.pagepress.org/journals/index.php/hr/article/view/7091; https://doaj.org/toc/2038-8322; https://doaj.org/toc/2038-8330 |
| DOI: | 10.4081/hr.2017.7091 |
| Access URL: | https://doaj.org/article/ac444d9f52934852ab829116789a9ffc |
| Accession Number: | edsdoj.444d9f52934852ab829116789a9ffc |
| Database: | Directory of Open Access Journals |
| ISSN: | 20388322 20388330 |
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| DOI: | 10.4081/hr.2017.7091 |
| Published in: | Hematology Reports |
| Language: | English |