Bibliographic Details
| Title: |
Successful treatment with metronidazole and paromomycin for fulminant amoebic colitis during cytotoxic chemotherapy in a patient with small-cell lung cancer |
| Authors: |
Aya Kitaoka, Kazuya Tanimura, Yuto Yasuda, Kensuke Nishioka, Yutaka Hirayama, Kiyoshi Uemasu, Daisuke Iwashima, Sou Arita, Toshiyuki Kitai, Susumu Hoshi, Emi Date, Norishige Iizuka, Ken-ichi Takahashi |
| Source: |
IDCases, Vol 26, Iss , Pp e01337- (2021) |
| Publisher Information: |
Elsevier, 2021. |
| Publication Year: |
2021 |
| Collection: |
LCC:Infectious and parasitic diseases |
| Subject Terms: |
Entamoeba histolytica, Fulminant amebic colitis, Activation, Chemotherapy, Small-cell lung cancer, Infectious and parasitic diseases, RC109-216 |
| More Details: |
We report the case of a 64-year-old man with advanced small-cell lung cancer who developed fulminant amoebic colitis during cytotoxic chemotherapy. During the first cycle of carboplatin/etoposide treatment, febrile neutropenia and grade 4 neutropenia developed. Because diarrhea, abdominal pain, and bloody stool were observed, abdominal computed tomography was performed, showing intussusception, and extensive colectomy and colostomy were performed. Histopathology of the colon revealed gastrointestinal necrosis and perforation due to Entamoeba histolytica infection. Amoebiasis improved after treatment with metronidazole and paromomycin. The second cycle of carboplatin/etoposide with dose reduction was completed, resulting in a partial response to small-cell lung cancer.The results of this case suggest that paromomycin is an additional option for amoebiasis during cytotoxic chemotherapy, and persistent diarrhea during cytotoxic chemotherapy should alert clinicians to consider the development of amoebiasis. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2214-2509 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2214250921002936; https://doaj.org/toc/2214-2509 |
| DOI: |
10.1016/j.idcr.2021.e01337 |
| Access URL: |
https://doaj.org/article/dc440a34809c48368a23a348d348c76f |
| Accession Number: |
edsdoj.440a34809c48368a23a348d348c76f |
| Database: |
Directory of Open Access Journals |
