Liver X Receptor β Related to Tumor Progression and Ribosome Gene Expression in Papillary Thyroid Cancer
| Title: | Liver X Receptor β Related to Tumor Progression and Ribosome Gene Expression in Papillary Thyroid Cancer |
|---|---|
| Authors: | Seonhyang Jeong, In-Kyu Kim, Hyunji Kim, Moon Jung Choi, Jandee Lee, Young Suk Jo |
| Source: | Endocrinology and Metabolism, Vol 35, Iss 3, Pp 656-668 (2020) |
| Publisher Information: | Korean Endocrine Society, 2020. |
| Publication Year: | 2020 |
| Collection: | LCC:Diseases of the endocrine glands. Clinical endocrinology |
| Subject Terms: | thyroid neoplasms, obesity, metabolism, prognosis, liver x receptors, ribosomes, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| More Details: | Background Intracellular lipid deposition has been reported in thyroid glands in obese animal and human. To understand the regulatory mechanism of lipid metabolism in thyroid cancer, we investigated the expression status of liver X receptor (LXR) and analyzed its clinicopathological characteristics and molecular biological features. Methods Expression status of LXR and its transcriptional targets in human cancers were analyzed using The Cancer Genome Atlas (TCGA). The gene-sets related to high LXRβ expression was investigated by gene set enrichment analysis (GSEA) using Kyoto Encyclopedia of Genes and Genomes (KEGG) signaling pathways and gene ontology biologic process. Quantitative reverse transcription polymerase chain reaction was performed in thyroid cancer samples using our validation cohort. Results In contrast to low expression of LXRα, LXRβ was highly expressed in thyroid cancer compared to the other types of human cancers. High LXRβ expression was correlated with the expression of LXRβ transcriptional targets genes, such as apolipoprotein C1 (APOC1), APOC2, apolipoprotein E (APOE), ATP binding cassette subfamily G member 8 (ABCG8), sterol regulatory elementbinding protein 1c (SREBP1c), and SPOT14. Furthermore, High LXRβ expression group indicated poor clinicopathological characteristics and aggressive molecular biological features independently from the drive mutation status. Mechanistically, high LXRβ expression was coordinately related to ribosome-related gene sets. Conclusion The mechanistic link between LXRβ and ribosomal activity will be addressed to develop new diagnostic and therapeutic targets in thyroid cancers. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English Korean |
| ISSN: | 2093-596X 2093-5978 |
| Relation: | http://www.e-enm.org/upload/pdf/enm-2020-667.pdf; https://doaj.org/toc/2093-596X; https://doaj.org/toc/2093-5978 |
| DOI: | 10.3803/EnM.2020.667 |
| Access URL: | https://doaj.org/article/43d3e8b727be4cc5bf9cadfb75071ff0 |
| Accession Number: | edsdoj.43d3e8b727be4cc5bf9cadfb75071ff0 |
| Database: | Directory of Open Access Journals |
| ISSN: | 2093596X 20935978 |
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| DOI: | 10.3803/EnM.2020.667 |
| Published in: | Endocrinology and Metabolism |
| Language: | English Korean |