Bibliographic Details
| Title: |
Sodium MRI with 3D-cones as a measure of tumour cellularity in high grade serous ovarian cancer |
| Authors: |
Surrin S. Deen, Frank Riemer, Mary A. McLean, Andrew B. Gill, Joshua D. Kaggie, James T. Grist, Robin Crawford, John Latimer, Peter Baldwin, Helena M. Earl, Christine A. Parkinson, Sarah A. Smith, Charlotte Hodgkin, Elizabeth Moore, Mercedes Jimenez-Linan, Cara R. Brodie, Helen C. Addley, Susan J. Freeman, Penelope L. Moyle, Evis Sala, Martin J. Graves, James D. Brenton, Ferdia A. Gallagher |
| Source: |
European Journal of Radiology Open, Vol 6, Iss , Pp 156-162 (2019) |
| Publisher Information: |
Elsevier, 2019. |
| Publication Year: |
2019 |
| Collection: |
LCC:Medical physics. Medical radiology. Nuclear medicine |
| Subject Terms: |
Medical physics. Medical radiology. Nuclear medicine, R895-920 |
| More Details: |
The aim of this study was to assess the feasibility of rapid sodium MRI (23Na-MRI) for the imaging of peritoneal cancer deposits in high grade serous ovarian cancer (HGSOC) and to evaluate the relationship of 23Na-MRI with tumour cellularity. 23Na-MRI was performed at 3 T on twelve HGSOC patients using a 3D-cones acquisition technique. Tumour biopsies specimens were collected after imaging and cellularity was measured from histology. Total 23Na-MRI scan time for each patient was approximately 11 min. At an isotropic resolution of 5.6 mm, signal-to-noise ratios (SNRs) of 82.2 ± 15.3 and 15.1 ± 7.1 (mean ± standard deviation) were achieved for imaging of tumour tissue sodium concentration (TSC) and intracellular weighted sodium concentration (IWS) respectively. Tumour TSC and IWS concentrations were: 56.8 ± 19.1 mM and 30.8 ± 9.2 mM respectively and skeletal muscle TSC and IWS concentrations were 33.2 ± 16.3 mM and 20.5 ± 9.9 mM respectively. There were significant sodium concentration differences between cancer and skeletal muscle, Wilcoxon signed-rank test, P |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2352-0477 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S2352047719300176; https://doaj.org/toc/2352-0477 |
| DOI: |
10.1016/j.ejro.2019.04.001 |
| Access URL: |
https://doaj.org/article/43b9f269f1f743b1a86653c4529bf6eb |
| Accession Number: |
edsdoj.43b9f269f1f743b1a86653c4529bf6eb |
| Database: |
Directory of Open Access Journals |
