Bibliographic Details
| Title: |
Prevalence, genomic characteristics, and pathogenicity of fowl adenovirus 2 in Southern China |
| Authors: |
Junqin Zhang, Zimin Xie, Yanlin Pan, Zuoxin Chen, Yunzhen Huang, Linlin Li, Jiawen Dong, Yong Xiang, Qi Zhai, Xingying Li, Minhua Sun, Shujian Huang, Ming Liao |
| Source: |
Poultry Science, Vol 103, Iss 1, Pp 103177- (2024) |
| Publisher Information: |
Elsevier, 2024. |
| Publication Year: |
2024 |
| Collection: |
LCC:Animal culture |
| Subject Terms: |
fowl adenovirus 2, prevalence, complete genome, recombination, pathogenicity, Animal culture, SF1-1100 |
| More Details: |
ABSTRACT: In recent years, the occurrence of fowl adenovirus 2 (FAdV-2) has been on the rise in China, posing a significant threat to the poultry industry. This study aimed to investigate the epidemiology, phylogenetic relationship, genomic characteristics, and pathogenicity of FAdV-2. The epidemiological analysis revealed the detection of multiple FAdV serotypes, including FAdV-1, FAdV-2, FAdV-3, FAdV-4, FAdV-8a, FAdV-8b, and FAdV-11 serotypes. Among them, FAdV-2 exhibited the highest proportion, accounting for 21.05% (8/38). The complete genomes of these 8 FAdV-2 strains were sequenced. Genetic evolution analysis indicated that these FAdV-2 strains formed a separate branch within the FAdV-D group, sharing 94.60 to 97.90% nucleotide similarity with the reference FAdV-2 and FAdV-11 strains. Notably, the recombination analysis revealed that 5 out of the 8 FAdV-2 strains, exhibited recombination events between FAdV-2 and FAdV-11. The recombination regions involved Hexon, Fiber, ORF19 genes and 3′ end. Furthermore, pathogenicity experiments demonstrated that recombinant FAdV-2 XX strain is capable of inducing mortality rate of 66.70% and causing more severe hepatitis hydropericardium syndrome (HHS) in 6-wk-old specific-pathogen-free chickens. These findings contribute to our understanding of the prevalence, genomic characteristics, and the pathogenicity of FAdV-2, providing foundations for FAdV-2 vaccine development. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
0032-5791 |
| Relation: |
http://www.sciencedirect.com/science/article/pii/S003257912300696X; https://doaj.org/toc/0032-5791 |
| DOI: |
10.1016/j.psj.2023.103177 |
| Access URL: |
https://doaj.org/article/43ac8e115d064ec1803f6bafc5ff27f4 |
| Accession Number: |
edsdoj.43ac8e115d064ec1803f6bafc5ff27f4 |
| Database: |
Directory of Open Access Journals |
