Academic Journal
Exploring peripheral fluid biomarkers for early detection of Alzheimer's disease in Down syndrome: A literature review
| Title: | Exploring peripheral fluid biomarkers for early detection of Alzheimer's disease in Down syndrome: A literature review |
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| Authors: | Charlotte Jacob, Marleen Tollenaere, Hanane Kachar, Marie-Claude Potier, Peter Paul De Deyn, Debby Van Dam |
| Source: | Heliyon, Vol 11, Iss 1, Pp e41445- (2025) |
| Publisher Information: | Elsevier, 2025. |
| Publication Year: | 2025 |
| Collection: | LCC:Science (General) LCC:Social sciences (General) |
| Subject Terms: | Blood, Urine, Neurofilament light chain, Monoaminergic biomarkers, DYRK1A, Cerebral amyloid angiopathy, Science (General), Q1-390, Social sciences (General), H1-99 |
| More Details: | People with Down Syndrome (DS) are at high risk of developing Alzheimer's disease dementia (AD) and cerebral amyloid angiopathy, which is a critical factor contributing to dementia in sporadic AD. Predicting and monitoring the decline and onset of dementia is a diagnostic challenge and of essence in daily care and support for people with DS. In this literature scoping review, we first summarize the different blood-based biomarkers for AD in DS. Next, we describe urine-based biomarkers for AD in DS and finally, we explore various blood-based biomarkers in the general AD population. Apart from the classic amyloid beta and Tau biomarkers, we also discuss more out-of-the-box biomarkers such as neurofilament light chain, Dual-specificity tyrosine-regulated kinase 1A, and monoaminergic biomarkers. These potential biomarkers could be a valuable addition to the established panel of fluid biomarkers. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 2405-8440 |
| Relation: | http://www.sciencedirect.com/science/article/pii/S2405844024174762; https://doaj.org/toc/2405-8440 |
| DOI: | 10.1016/j.heliyon.2024.e41445 |
| Access URL: | https://doaj.org/article/4348ec40194d4f818d6869a8fd1ff32a |
| Accession Number: | edsdoj.4348ec40194d4f818d6869a8fd1ff32a |
| Database: | Directory of Open Access Journals |
| ISSN: | 24058440 |
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| DOI: | 10.1016/j.heliyon.2024.e41445 |
| Published in: | Heliyon |
| Language: | English |