Bibliographic Details
| Title: |
New evidence for the effect of type 2 diabetes and glycemic traits on testosterone levels: a two-sample Mendelian randomization study |
| Authors: |
Chengyang Jiang, Yuwei Wang, Wenqiang Yang, Xinghai Yang |
| Source: |
Frontiers in Endocrinology, Vol 14 (2023) |
| Publisher Information: |
Frontiers Media S.A., 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Diseases of the endocrine glands. Clinical endocrinology |
| Subject Terms: |
Mendelian randomization, testosterone, diabetes, glycemic traits, sexual dysfunction, Diseases of the endocrine glands. Clinical endocrinology, RC648-665 |
| More Details: |
ObjectiveType 2 diabetes mellitus (T2DM) is an endocrine-related disease with an increasing incidence worldwide. Male sexual dysfunction is common in diabetic patients. Therefore, we designed a Mendelian randomization (MR) study to investigate the association of type 2 diabetes and 3 glycemic traits with testosterone levels.MethodsUncorrelated single nucleotide polymorphisms (SNPs) associated with T2DM (N = 228), fasting insulin (N = 38), fasting glucose (N = 71), and HbA1c (N = 75) at the genome-wide significance were selected as instrument variables. Genetic associations with testosterone levels (total testosterone, TT, bioavailable testosterone, BT, and sex hormone-binding globulin, SHBG) were obtained from the UK Biobank studies and other large consortia. Two-sample MR analysis was used to minimize the bias caused by confounding factors and response causality. Multivariable MR analysis was performed using Body mass index (BMI), Triglycerides (TG), LDL cholesterol (LDL), and adiponectin to adjust for the effects of potential confounders.ResultsType 2 diabetes mellitus was associated with the decrease of total testosterone (β: -0.021,95%CI: -0.032, -0.010, p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
1664-2392 |
| Relation: |
https://www.frontiersin.org/articles/10.3389/fendo.2023.1238090/full; https://doaj.org/toc/1664-2392 |
| DOI: |
10.3389/fendo.2023.1238090 |
| Access URL: |
https://doaj.org/article/e42bfea2d9b041caa9f6c026e10cfe56 |
| Accession Number: |
edsdoj.42bfea2d9b041caa9f6c026e10cfe56 |
| Database: |
Directory of Open Access Journals |
