Purple tea catechins exhibit high antiproliferative activity and synergism with cisplatin against the triple-negative breast cancer cell line 4T1
| Title: | Purple tea catechins exhibit high antiproliferative activity and synergism with cisplatin against the triple-negative breast cancer cell line 4T1 |
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| Authors: | Ndacyayisenga Joseph, Maina Esther N., Ngeny Lilian C., Wamunyokoli Fred, Tolo Festus M. |
| Source: | Archives of Biological Sciences, Vol 75, Iss 4, Pp 475-488 (2023) |
| Publisher Information: | University of Belgrade, University of Novi Sad, 2023. |
| Publication Year: | 2023 |
| Collection: | LCC:Biology (General) |
| Subject Terms: | tea catechins, tea clone, 4t1 cell line, combination index (ci), dose reduction index (dri), Biology (General), QH301-705.5 |
| More Details: | The objectives of this study were the selection of the best tea clones with high catechin content among the known tea clones in Rwanda and Kenya, the examination of their antiproliferative effects on the triple-negative breast cancer (TNBC) cell line (4T1), and an evaluation of their combination index with cisplatin. The quantification of catechin contents in 14 different tea clones and 5 different processed teas was performed by high-performance liquid chromatography (HPLC). A comparative study of antiproliferative activities of catechin extracts from purple, TRFK306, and BB35 tea clones on the TNBC cell line (4T1) was undertaken, and their combination index (CI) with cisplatin and the dose reduction index (DRI) were determined. The catechin extract from BB35 had the highest concentration of total catechins (817.81±24.2 mg/g DW). After 72 h, the catechin extracts from TRFK306 showed a high IC50 of 68.68±3.30 μg/mL. The catechin extracts from TRFK306 showed the best synergism with cisplatin (CI=0.59), and they reduced the doses of cisplatin with the highest DRI=3.74493. Catechin extracts from purple tea showed higher antiproliferative activity and synergism with cisplatin against the TNBC cell line. |
| Document Type: | article |
| File Description: | electronic resource |
| Language: | English |
| ISSN: | 0354-4664 1821-4339 |
| Relation: | https://doaj.org/toc/0354-4664; https://doaj.org/toc/1821-4339 |
| DOI: | 10.2298/ABS230816039N |
| Access URL: | https://doaj.org/article/42a6039891e442b0b8c03948cbb8f753 |
| Accession Number: | edsdoj.42a6039891e442b0b8c03948cbb8f753 |
| Database: | Directory of Open Access Journals |
| ISSN: | 03544664 18214339 |
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| DOI: | 10.2298/ABS230816039N |
| Published in: | Archives of Biological Sciences |
| Language: | English |