Bibliographic Details
| Title: |
Body composition is associated with changes in health-related quality of life in patients with knee and/or hip osteoarthritis |
| Authors: |
Jérémie Sellam, Francis Guillemin, Bernard Mazières, Anne-Christine Rat, Patrice Fardellone, Willy Ngueyon Sime |
| Source: |
RMD Open, Vol 11, Iss 1 (2025) |
| Publisher Information: |
BMJ Publishing Group, 2025. |
| Publication Year: |
2025 |
| Collection: |
LCC:Medicine |
| Subject Terms: |
Medicine |
| More Details: |
Objective The objective of this study was to analyse the association between body composition and changes in health-related quality of life (HRQoL) of patients followed for hip and knee osteoarthritis (OA).Methods Longitudinal data from the Knee and Hip OsteoArthritis Long-term Assessments (KHOALA) cohort, a multicentre cohort of 878 patients with symptomatic knee and/or hip OA, were used. The main outcome criteria were changes in patient-reported outcomes measures, the Study Short Form-36 (physical functioning, pain, mental health and vitality) and the OsteoArthritis Knee and Hip Quality Of Life (OAKHQOL)(physical activity, pain and mental health). Body composition measurements were obtained from dual X-ray absorptiometry (DXA) scans in a subsample of 381 patients at year 3. Body composition variables were fat mass index (FMI (kg/m²)), percentage of fat mass, trunk to leg fat mass ratio (TFM/LFM) and skeletal muscle mass index (SMI (kg/m²)). To account for the correlation of repeated measures in each individual, GEE models were used.Results 290 patients with knee and 114 patients with hip OA were included in the analysis. In multivariate analysis, higher FMI at baseline and the presence of low lean mass were independently associated with worse physical functioning over time (β −0.02, 95% CI −0.03 to −0.01, p |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2056-5933 |
| Relation: |
https://rmdopen.bmj.com/content/11/1/e004733.full; https://doaj.org/toc/2056-5933 |
| DOI: |
10.1136/rmdopen-2024-004733 |
| Access URL: |
https://doaj.org/article/42a0938cede94c9fa43b0b705d0423ea |
| Accession Number: |
edsdoj.42a0938cede94c9fa43b0b705d0423ea |
| Database: |
Directory of Open Access Journals |
