Bibliographic Details
| Title: |
Phenotyping asthma with airflow obstruction in middle-aged and older adults: a CADSET clinical research collaboration |
| Authors: |
Judith M Vonk, Torben Sigsgaard, Kian Fan Chung, Lies Lahousse, Maarten van den Berge, Jadwiga A Wedzicha, Judith Garcia-Aymerich, Anne Lindberg, Claus Vogelmeier, Helena Backman, Eva Rönmark, Ian M Adcock, Peter Alter, Alvar Agustí, Gavin C Donaldson, Guy G Brusselle, Rosa Faner, Howraman Meteran, Ahmed Edris, Nazanin Zounemat Kermani, Xander Bertels, Nuria Olvera |
| Source: |
BMJ Open Respiratory Research, Vol 10, Iss 1 (2023) |
| Publisher Information: |
BMJ Publishing Group, 2023. |
| Publication Year: |
2023 |
| Collection: |
LCC:Medicine
LCC:Diseases of the respiratory system |
| Subject Terms: |
Medicine, Diseases of the respiratory system, RC705-779 |
| More Details: |
Background The prevalence and clinical profile of asthma with airflow obstruction (AO) remain uncertain. We aimed to phenotype AO in population- and clinic-based cohorts.Methods This cross-sectional multicohort study included adults ≥50 years from nine CADSET cohorts with spirometry data (N=69 789). AO was defined as ever diagnosed asthma with pre-BD or post-BD FEV1/FVC 300 cells/µL), although only significant in population-based cohorts. Compared with asthma-only, AO patients were more often men, current smokers, with a lower BMI, had less often obesity and had more often chronic bronchitis. Compared with COPD-only, AO patients were younger, less often current smokers and had less pack-years. In the general population, AO patients had a higher risk of coronary artery disease than asthma-only and COPD-only (OR=2.09 (95% CI 1.26 to 3.47) and OR=1.89 (95% CI 1.10 to 3.24), respectively) and of depression (OR=1.41 (95% CI 1.19 to 1.67)), osteoporosis (OR=2.30 (95% CI 1.43 to 3.72)) and gastro-oesophageal reflux disease (OR=1.68 (95% CI 1.06 to 2.68)) than COPD-only, independent of age, sex, smoking status and BMI.Conclusions AO is a relatively prevalent respiratory phenotype associated with more dyspnoea and a higher risk of coronary artery disease and elevated blood eosinophil counts in the general population compared with both asthma-only and COPD-only. |
| Document Type: |
article |
| File Description: |
electronic resource |
| Language: |
English |
| ISSN: |
2052-4439 |
| Relation: |
https://bmjopenrespres.bmj.com/content/10/1/e001760.full; https://doaj.org/toc/2052-4439 |
| DOI: |
10.1136/bmjresp-2023-001760 |
| Access URL: |
https://doaj.org/article/4246d986f53a452a9373d730efc8e7de |
| Accession Number: |
edsdoj.4246d986f53a452a9373d730efc8e7de |
| Database: |
Directory of Open Access Journals |
